Evidence map›Paper›PMID 40914753›Full record

ArticleMolecular psychiatry2026

GABA

Paulina B Lukow, Julia J Schubert, Mario Severino, Samuel R Knight, Amanda Kiemes, Nicholas R Livingston, James Davies, Andrea de Micheli, Thomas J Spencer, Paolo Fusar-Poli and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Paulina B LukowInstitute of Cognitive Neuroscience, University College London, Alexandra House, 17-19 Queen Square, London, WC1N 3AZ, UK. p.lukow@ucl.ac.uk.ORCID http://orcid.org/0000-0002-6796-9102
Julia J SchubertDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.
Mario SeverinoDepartment of Information Engineering, University of Padova, Via Giovanni Gradenigo, 6B, 35131, Padova, Italy.
Samuel R KnightDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.ORCID http://orcid.org/0000-0003-3420-3722
Amanda KiemesDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.
Nicholas R LivingstonDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.ORCID http://orcid.org/0000-0002-6582-2545
James DaviesInvicro, Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Andrea de MicheliDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.
Thomas J SpencerDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.
Paolo Fusar-PoliDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.ORCID http://orcid.org/0000-0003-3582-6788
Beate HaegeSouthwark Team for Early Psychosis, South London and Maudsley NHS Foundation Trust, St Giles House, 1 St Giles Road, London, SE5 7UD, UK.
Natasha VorontsovaDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.
Jacek DonocikLewisham Early Intervention Service, South London and Maudsley NHS Foundation Trust, 59 Cordwell Road, Lewisham, London, SE13 5QY, UK.
Eugenii A RabinerInvicro, Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Anthony A GraceDepartments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, 15260, USA.ORCID http://orcid.org/0000-0003-1864-5504
Steven C WilliamsDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.ORCID http://orcid.org/0000-0003-4299-1941
Philip McGuireDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.ORCID http://orcid.org/0000-0003-4381-0532
Mattia VeroneseDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.ORCID http://orcid.org/0000-0003-3562-0683
Federico E TurkheimerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.ORCID http://orcid.org/0000-0002-3766-3815
Gemma ModinosDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.ORCID http://orcid.org/0000-0002-7870-066X

Funding

Gating of Information Flow Within the Nucleus Accumbens (Supplement)R01MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY A GRACE · 1997 to 2026
$7.2M
Gating of Information Flow Within the Nucleus AccumbensR37MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRACE, ANTHONY A · 2007 to 2016
$3.3M
NIMH NIH HHS R01 MH057440NIMH NIH HHS R37 MH057440Wellcome TrustWellcome Trust (Wellcome) 202397/Z/16/Z
6 · The paper itself

Abstract

Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been described in schizophrenia and in people at clinical high-risk for psychosis (CHRp). We have also found decreases in hippocampal GABA

Indexed as

Psychotic DisordersReceptors, GABA-AAdolescentAdultAzidesBenzodiazepinesBrainCarbon RadioisotopesFemalegamma-Aminobutyric AcidHippocampusHumansMalePositron-Emission TomographySchizophreniaYoung AdultAzidesBenzodiazepinesCarbon RadioisotopesGABRA5 protein, humangamma-Aminobutyric AcidReceptors, GABA-ARo 15-4513

Identifiers

PMID40914753
PMCPMC12815687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.