Evidence map›Paper›PMID 40914728›Full record

Observational studyBritish journal of anaesthesia2025

Association of preoperative nocturnal hypoxaemia nadir and fentanyl ventilatory sensitivity in children with obstructive sleep apnoea undergoing general anaesthesia: a multicentre clinical cohort study.

Adam C Adler, Elaina E Lin, Anna H Messner, Tara L Rosenberg, Shelly Pecorella, Aidan Keleghan, Spencer Faircloth, T Wesley Templeton, Lynnette Harris, Sabina A Khan and 4 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05051189 (Effect of Opioids on Central Control of Ventilation in Children With Obstructive Sleep Apnea), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05051189 early_phase1completednot on this map

Effect of Opioids on Central Control of Ventilation in Children With Obstructive Sleep Apnea

TypeinterventionalSponsorBaylor College of MedicineRan2021 to 2024Enrolled90ConditionsOSA, Opioid, AdenotonsillectomyArmsFentanyl Citrate
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Adam C AdlerDepartment of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA. Electronic address: adamcadler@gmail.com.
Elaina E LinDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Pennsylvania, Philadelphia, PA, USA; The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Anna H MessnerBaylor College of Medicine, Houston, TX, USA; Department of Otolaryngology/Head & Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Tara L RosenbergBaylor College of Medicine, Houston, TX, USA; Department of Otolaryngology/Head & Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Shelly PecorellaDepartment of Anesthesiology, Atrium Health, Wake Forest Baptist, Winston-Salem, NC, USA; Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Aidan KeleghanDepartment of Anesthesiology, Atrium Health, Wake Forest Baptist, Winston-Salem, NC, USA.
Spencer FairclothDepartment of Anesthesiology, Atrium Health, Wake Forest Baptist, Winston-Salem, NC, USA.
T Wesley TempletonDepartment of Anesthesiology, Atrium Health, Wake Forest Baptist, Winston-Salem, NC, USA; Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Lynnette HarrisDepartment of Anesthesiology, Atrium Health, Wake Forest Baptist, Winston-Salem, NC, USA.
Sabina A KhanDepartment of Anesthesiology, Division of Pediatric Anesthesiology, UT Health Houston, Houston, TX, USA; McGovern Medical School, Houston, TX, USA.
Greesha S PednekarDepartment of Anesthesiology, Division of Pediatric Anesthesiology, UT Health Houston, Houston, TX, USA; McGovern Medical School, Houston, TX, USA.
Duc T NguyenDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Arvind ChandrakantanDepartment of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA.
Britta S von Ungern-SternbergDepartment of Anaesthesia and Pain Management, Perth Children's Hospital, Perth, WA, Australia; Division of Emergency Medicine, Anaesthesia and Pain Medicine, The University of Western Australia, Perth, WA, Australia; Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, WA, Australia; Perioperative Medicine Team, Perioperative Care Program, The Kids Research Institute Australia, Perth, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnoea (OSA) has been thought to increase the risk of respiratory depression from opioids. The primary aim of this study was to assess whether preoperative hypoxaemia by sleep study pulse oximetry imparts greater opioid sensitivity.

methodsA multicentre observational cohort study with in-cohort dose randomisation was performed in children 2-8 yr of age with OSA undergoing adenotonsillectomy. Ninety patients were assigned to one of two Spo

resultsNinety patients underwent in-cohort randomisation (Spo

conclusionsSingle-dose fentanyl ventilatory effects in paediatric OSA patients during sevoflurane anaesthesia were not associated with preoperative nocturnal hypoxaemia nadir. Fentanyl dosing in children with OSA should not be determined by sleep study Spo CLINICAL

trial registrationNCT05051189.

Indexed as

Analgesics, OpioidAnesthesia, GeneralFentanylHypoxiaSleep Apnea, ObstructiveAdenoidectomyChildChild, PreschoolCohort StudiesFemaleHumansMaleOximetryPreoperative CareTonsillectomyAnalgesics, OpioidFentanylintermittent hypoxaemiaobstructive sleep apnoeaopioidpaediatric anaesthesia

Identifiers

PMID40914728
PMCPMC12597378

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.