Trial reportThe Journal of nutrition2025
Microbiota-Dependent Fiber Responses: A Proof-of-Concept Study on Short-Chain Fatty Acid Production in Prevotella- and Bacteroides-Dominated Healthy Individuals.
Trial report in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Review
- From diet to function: using synthetic microbial communities to map gut microbial interactions.NPJ biofilms and microbiomes · 2026Review
- Review
- The Oral-Gut-Immune-Nutrition Axis in Rheumatoid Arthritis: Molecular Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Soy and the gut microbiome: a bi-directional relationship shaping nutrition and health.European journal of nutrition · 2026Review
- Altered gut microbiota and serum metabolite profiles characterize postmenopausal bone loss: insights into the gut-bone axis.Frontiers in microbiology · 2026Article
- Precision prebiotics: Engineering food-derived polysaccharides to target specific SCFA-producing taxa for neuroprotection via the microbiota-gut-brain axis.Current research in food science · 2026Review
- The dual roles ofFrontiers in oncology · 2026Review
- Interpretable machine learning uncovers core seminal microbial signatures in idiopathic oligoasthenospermia.Frontiers in cellular and infection microbiology · 2026Article
- Preliminary study on the effects of different dietary spermine levels on intestinal function, microflora, and metabolism in weaned Wuzhishan piglets.Frontiers in veterinary science · 2026Article
- A Review of Global Patterns in Gut Microbiota Composition, Health and Disease: Locating South Africa in the Conversation.Microorganisms · 2025Review
- Nutrigenomics meets multi-omics: integrating genetic, metabolic, and microbiome data for personalized nutrition strategies.Genes & nutrition · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDietary fiber supports metabolic health via microbial fermentation, producing short-chain fatty acids (SCFAs). However, metabolic responses to fiber vary between individuals, potentially due to differences in gut microbiota composition. The Prevotella-to-Bacteroides ratio has emerged as a potential biomarker for fiber responsiveness.
objectivesThis study examined how stratified fiber supplementation affects microbial and metabolic outcomes in individuals with Prevotella (P-type)- or Bacteroides-dominated (B-type) microbiota.
methodsIn this single-blinded, randomized crossover study, 23 healthy adults were classified as P-type (≥10% Prevotella) or B-type (≥10% Bacteroides) via 16S rRNA sequencing. Participants consumed 15 g/d of arabinoxylan (AX), inulin (INU), or placebo (PLA) for 1 wk each, with 2-wk washouts. After each phase, fasting and postprandial plasma SCFAs, branched-chain fatty acids (BCFAs), breath hydrogen, glucose, insulin, peptide YY, cholesterol, appetite ratings, and fecal microbiota were assessed. Data were analyzed using repeated-measures analysis of variance, the Friedman test, and multivariate microbiome analysis.
resultsIn P-types, AX increased fasting propionate compared with PLA (P = 0.04). In B-types, AX increased fasting propionate compared with INU (P = 0.02) and tended to elevate postprandial propionate compared with PLA in the first 60 min after breakfast (P = 0.05). AX also increased postprandial acetate compared with PLA in B-types (P = 0.04). INU reduced fasting BCFAs in B-types (P < 0.05) but did not increase SCFAs. Breath hydrogen varied widely in B-types after INU but not in P-types. Neither fiber affected glucose, insulin, or PYY. AX reduced appetite ratings in P-types (P < 0.05). INU increased Anaerostipes and Bifidobacterium and reduced Phocaeicola in both groups (q < 0.25). AX increased Fusicatenibacter in B-types (q = 0.18) and Paraprevotella in P-types (q = 0.17).
conclusionsB-types exhibited fiber-specific shifts in SCFA and BCFA metabolism and breath hydrogen, whereas P-types displayed a more limited overall response, with fewer metabolic and microbial parameters affected. These findings highlight the complexity of diet-microbiota interactions and support the potential relevance for microbiota-based nutrition strategies. This trial (PERIFIB) was registered at the German Clinical Trials register (DRKS) as DRKS00028898.
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