Evidence map›Paper›PMID 40914449›Full record

ArticleNitric oxide : biology and chemistry2025

Role of hydrogen sulfide in catalyzing the formation of NO-ferroheme.

Laxman Poudel, Thilini Karunarathna, Stephen Baker, Elmira Alipour, Matthew R Dent, Jesús Tejero, Mark T Gladwin, Anthony W DeMartino, Daniel B Kim-Shapiro

Abstract read
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In one paragraph

Article in Nitric oxide : biology and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The first and second zinc finger domains from Poly-ADP-ribose polymerase 1 (PARP1) are modified by hydrogen sulfide.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laxman PoudelDepartment of Physics, Wake Forest University, Winston-Salem, NC, 27109, USA.
Thilini KarunarathnaDepartment of Physics, Wake Forest University, Winston-Salem, NC, 27109, USA.
Stephen BakerDepartment of Physics, Wake Forest University, Winston-Salem, NC, 27109, USA.
Elmira AlipourDepartment of Physics, Wake Forest University, Winston-Salem, NC, 27109, USA.
Matthew R DentHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Jesús TejeroHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15260, USA; (D)epartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Mark T GladwinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Anthony W DeMartinoDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address: ADeMartino@som.umaryland.edu.
Daniel B Kim-ShapiroDepartment of Physics, Wake Forest University, Winston-Salem, NC, 27109, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC, 27109, USA. Electronic address: shapiro@wfu.edu.

Funding

Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide HomeostasisR01HL098032 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin · 2009 to 2026
$12.5M
Antidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9M
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cellsR00HL168224 · NHLBI · WAYNE STATE UNIVERSITY · PI Matthew Ryan Dent · 2024 to 2026
$746k
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cellsK99HL168224 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2023 to 2024
$326k
NHLBI NIH HHS K99 HL168224NHLBI NIH HHS R00 HL168224NHLBI NIH HHS R01 HL098032NHLBI NIH HHS R01 HL125886
6 · The paper itself

Abstract

We recently demonstrated a rapid reaction between labile ferric heme and nitric oxide (NO) in the presence of reduced glutathione (GSH) or other small thiols in a process called thiol-catalyzed reductive nitrosylation, yielding a novel signaling molecule, labile nitrosyl ferrous heme (NO-ferroheme), which we and others have shown can regulate vasodilation and platelet homeostasis. Red blood cells (RBCs) contain high concentrations of GSH, and NO can be generated in the RBC via nitrite reduction and/or RBC endothelial nitric oxide synthase (eNOS) so that NO-ferroheme could, in principle, be formed in the RBC. NO-ferroheme may also form in other cells and compartments, including in plasma, where another small and reactive thiol species, hydrogen sulfide (H

Indexed as

Ferrous CompoundsHemeHydrogen SulfideNitric OxideCatalysisErythrocytesGlutathioneHeminHumansSerum AlbuminFerrous CompoundsGlutathioneHemeHeminHydrogen SulfideNitric OxideSerum Albumin

Identifiers

PMID40914449
PMCPMC12710387

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.