Evidence map›Paper›PMID 40914434›Full record

ArticleNeurobiology of disease2025

The absence of Parkin in hTau mice leads to synaptic mitochondrial dysfunction, alterations to the synaptic proteome, and increased phosphorylated tau in the Hippocampus.

L Daniel Estrella, Xiaoke Xu, Collin White, Jane E Manganaro, Lexi Sheldon, Trey Farmer, Kelly L Stauch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L Daniel EstrellaUniversity of Nebraska Medical Center, College of Medicine, Department of Neurological Sciences, Omaha, NE, USA.
Xiaoke XuUniversity of Nebraska Medical Center, College of Medicine, Department of Neurological Sciences, Omaha, NE, USA.
Collin WhiteUniversity of Nebraska Medical Center, College of Medicine, Department of Neurological Sciences, Omaha, NE, USA.
Jane E ManganaroUniversity of Nebraska Medical Center, College of Medicine, Department of Neurological Sciences, Omaha, NE, USA.
Lexi SheldonUniversity of Nebraska Medical Center, College of Medicine, Department of Neurological Sciences, Omaha, NE, USA.
Trey FarmerUniversity of Nebraska Medical Center, College of Medicine, Department of Neurological Sciences, Omaha, NE, USA.
Kelly L StauchUniversity of Nebraska Medical Center, College of Medicine, Department of Neurological Sciences, Omaha, NE, USA. Electronic address: kelly.stauch@unmc.edu.

Funding

Mechanisms of Presynaptic Energetic Failure Due to Age-Related Pathologic Tau AccumulationR01AG059785 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI STAUCH, KELLY LYNN · 2018 to 2022
$1.9M
NIA NIH HHS R01 AG059785
6 · The paper itself

Abstract

Amongst the major histopathological hallmarks in Alzheimer's disease are intracellular neurofibrillary tangles consisting of hyperphosphorylated and aggregated Tau, synaptic dysfunction, and synapse loss. We have previously shown evidence of synaptic mitochondrial dysfunction in a mouse model of Tauopathy that overexpresses human Tau (hTau). Here, we questioned whether the levels or activity of Parkin, an E3 ubiquitin ligase involved in mitophagy, can influence Tau-induced synaptic mitochondrial dysfunction. Here, we generated novel mouse strains by crossing hTau mice with either Parkin knockout mice or mice expressing mutant Parkin (Parkin

Indexed as

HippocampusMitochondriaProteomeSynapsesTauopathiestau ProteinsUbiquitin-Protein LigasesAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPhosphorylationSynaptosomesMAPT protein, humanparkin proteinProteometau ProteinsUbiquitin-Protein LigasesAlzheimer's diseaseMitophagyParkinParkinW402APhosphorylated TauSynapseSynaptic mitochondriaTauopathy

Identifiers

PMID40914434
PMCPMC12680073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.