ArticleSeminars in arthritis and rheumatism2025
MRI versus radiography as eligibility screening tool for knee osteoarthritis clinical trials: Data from the osteoarthritis initiative.
Article in Seminars in arthritis and rheumatism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Association between low bone mineral density and subchondral insufficiency fractures of the knee in women, and influence of radial meniscal root tears.Diagnostic and interventional imaging · 2026Article
- Association between radial meniscal tears with and without posterior root involvement and subchondral insufficiency fracture of the knee on MRI: The mediating role of meniscal extrusion.Diagnostic and interventional imaging · 2026Article
- The role of radiography and MRI as screening tools and outcome measures in clinical trials of knee osteoarthritis: a perspective on the current status and outlook.Therapeutic advances in musculoskeletal disease · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo estimate the prevalence of knee structural pathologies that may warrant exclusion from disease-modifying osteoarthritis drug (DMOAD) trials, based on MRI versus radiography, among participants who would otherwise be considered eligible for enrollment based on commonly used radiographic inclusionary criteria.
methodsWe selected participants from the baseline visit of the Osteoarthritis Initiative that met radiographic structural and clinical eligibility criteria for a DMOAD clinical trial: Radiographic OA (Kellgren-Lawrence grade 2 or 3 with medial minimum joint space width ≥ 1.5 mm); and WOMAC knee pain score between 8 and 18 (0-20 scale). A musculoskeletal radiologist read radiographs and a shortened 3-T MRI protocol for structural pathologies that have been suggested as exclusionary from DMOAD clinical trial participation, as proposed by the Rapid Osteoarthritis MRI Eligibility Score (ROAMES), including meniscal root tears, subchondral insufficiency fractures, osteonecrosis, tumors and bone marrow infiltration, and acute traumatic changes.
resultsAmong 380 eligible participants (219 KL2 knees, 161 KL3 knees), structural pathologies that warrant exclusion from clinical trials were found in 38 knees (10 %) based on MRI, versus three knees (0.8 %) on radiography. Based on MRI, the estimated probability of an exclusionary finding in a KL2 knee was 0.06 (95 %CI: 0.03, 0.09), and 0.16 (95 %CI: 0.10, 0.21) in a KL3 knee. The most common finding was complete meniscus posterior root tear (31 knees, 8.2 %).
conclusionStructural pathologies that are unlikely to respond to investigational DMOADs were found in ∼10 % of eligible participants based on MRI screening, largely driven by complete meniscal root tears, while these findings were not visible on radiographs.
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