Evidence map›Paper›PMID 40913828›Full record

ArticleJournal of neuroimmunology2025

Sex differences in the neuroimmune response following heavy, binge-like alcohol exposure in adolescent rats.

Catherine E Van Doorn, Natalie Nawarawong, Deann M Hopkins, Hui Peng, James R Pauly, Kimberly Nixon

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Catherine E Van DoornUniversity of Kentucky, Department of Pharmaceutical Sciences, Lexington, KY 40536, United States of America.
Natalie NawarawongThe University of Texas at Austin, College of Pharmacy, Division of Pharmacology & Toxicology, Austin, TX, 78712, United States of America.
Deann M HopkinsUniversity of Kentucky, Department of Pharmaceutical Sciences, Lexington, KY 40536, United States of America.
Hui PengUniversity of Kentucky, Department of Pharmaceutical Sciences, Lexington, KY 40536, United States of America.
James R PaulyUniversity of Kentucky, Department of Pharmaceutical Sciences, Lexington, KY 40536, United States of America.
Kimberly NixonThe University of Texas at Austin, College of Pharmacy, Division of Pharmacology & Toxicology, Austin, TX, 78712, United States of America. Electronic address: Kim.nixon@austin.utexas.edu.

Funding

Ethanol Alteration of the Neurogenic NicheR01AA016959 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI NIXON, KIMBERLY · 2007 to 2022
$4.8M
Research Training in Drug Abuse BehaviorT32DA035200 · NIDA · UNIVERSITY OF KENTUCKY · PI CRAIG R RUSH, William Walton Stoops · 2013 to 2026
$4.4M
Microglia and Adolescent Susceptibility to Developing an Alcohol Use DisorderR01AA025591 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI NIXON, KIMBERLY · 2017 to 2021
$2.1M
NIAAA NIH HHS R01 AA016959NIAAA NIH HHS R01 AA025591NIDA NIH HHS T32 DA035200
6 · The paper itself

Abstract

Adolescents who consume alcohol show a high prevalence of binge drinking, which has been linked to brain damage and neuroimmune reactions that increase risk for developing an alcohol use disorder (AUD). Adolescent female drinking patterns have surpassed males, yet little is known about damaging effects of alcohol in females. Known sex differences in neuroimmune reactivity, specifically microglial reactivity, suggest that the female brain will differ from males. Therefore, we examined indicators of neuroimmune activation and neurodegeneration following 2 days of heavy, bingelike exposure in adolescent male and female rats. Translocator protein 18kD (TSPO) expression assessed by [

Indexed as

Binge DrinkingBrainEthanolNeuroimmunomodulationSex CharacteristicsAnimalsFemaleHippocampusMaleRatsRats, Sprague-DawleyEthanolAdolescenceAlcohol use disorderCytokinesEthanolNeuroimmune

Identifiers

PMID40913828
PMCPMC12637034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.