ArticleEuropean journal of nutrition2025
Anti-colorectal cancer effect and mechanism of a polysaccharide from Ruditapes philippinarum.
Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Pharmacokinetic Profiling Evaluation ofMarine drugs · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
purposeColorectal cancer (CRC) is the most common malignant tumor with a persistently high mortality rate worldwide. This study aimed to explore the anti-CRC effect and mechanisms of Ruditapes philippinarum polysaccharides (RPP).
methodsWe used HT-29 cells and HT-29 tumor-bearing mice to study the anti-CRC effects and mechanisms of RPP in vitro and in vivo.
resultsAnimal experiments demonstrated that RPP-treated groups increased expression levels of Bax and cleaved caspase-3 proteins while reducing expression levels of Bcl-2 and Clusterin proteins in mice bearing HT-29 tumors. These results suggested the potential involvement of the mitochondrial apoptotic pathway in HT-29 cells apoptosis. Meanwhile, expression levels of β-catenin and its subsequent target proteins, such as Survivin, C-myc, and Cyclin D1, were suppressed, suggesting that RPP arrested the cell cycle of HT-29 cells in the G0/G1 phase by inhibiting the Wnt/β-catenin pathway. Additionally, RPP suppressed levels of TNF-α, IL-6, and IL-1β, and then alleviated the inflammatory response.
conclusionOverall, these findings could provide a new insight that RPP are promising polysaccharides to combat CRC as drugs or preventive health products.
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Registered trials
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