ReviewOrthopadie (Heidelberg, Germany)2025
[Debridement, antimicrobial therapy, and implant retention for acute periprosthetic infections].
Review in Orthopadie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [Risk adjustment as a prerequisite for quality assessment in certification and registry analyses].Orthopadie (Heidelberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe DAIR procedure (debridement, antibiotic therapy, and implant retention) represents a treatment option for acute periprosthetic joint infections (PJI). Compared to revision arthroplasty, it is technically less invasive and, under appropriate indications, can preserve a well-fixed endoprosthesis. However, treatment success depends on numerous patient-, pathogen-, and procedure-related factors.
methodsBased on a comprehensive review of current international studies and guidelines, we systematically analyzed the key factors influencing the success of DAIR. In addition, clinical experiences from our orthopedic department, particularly with staphylococcal infections, were evaluated and integrated.
resultsCritical success factors for DAIR include early intervention within 3 weeks of symptom onset, exchange of all mobile components, stable implant fixation, intact soft tissue envelope, and consideration of risk factors such as advanced age, immunosuppressive therapy, COPD, or rheumatoid arthritis. The choice of antibiotic regimen, especially rifampicin-based combination therapy for staphylococcal infections, affects the outcome significantly.
conclusionDAIR can be an effective treatment option with favorable healing rates under clearly defined conditions. Careful patient selection, a multidisciplinary case review, and strict adherence to surgical and antimicrobial standards are essential to improve success rates. In unfavorable clinical situations, a direct implant revision should be considered instead.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.