Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Effective nutritional intervention improves the health-related quality of life (HRQL) of undernourished children with cancer: results of a randomized, controlled phase 3 trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The impact of ready-to-use-therapeutic-food (RUTF) on micronutrient levels in undernourished children with cancer: a randomized open-labelled controlled study.European journal of clinical nutrition · 2026Article
- Evaluating a Global Clinical Nutrition Program for Pediatric Oncology in Resource-Limited Settings.Annals of global health · 2026Article
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5 authors.
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Abstract
purposeThe association of nutritional intervention and health-related quality of life (HRQL) was examined in children with cancer.
methodsUndernourished children with cancer (N = 260) were randomized 1:1 to standard nutritional therapy (SNT) or SNT + Ready to Use Therapeutic Food (RUTF). HRQL was assessed using the Health Utilities Index® (HUI) at study entry and 6 weeks later. HUI has two systems, HUI2 and HUI3, with derived categories of disability. Scores after SNT and SNT + RUTF were compared.
resultsAt study entry there were no significant differences in HRQL scores between the two treatment arms. After 6 weeks of nutritional intervention, median overall HUI2 scores were comparable-0.90 with RUTF and 0.89 with SNT (p = 0.317)-but overall HUI3 scores were 0.90 and 0.79 (p = 0.009), respectively. At study entry and 6 weeks, 87 (35%) and 116 (46.6%) subjects had no or mild disability, and 162 (65%) and 133 (53.4%) had moderate or severe disability (p < 0.001) respectively using HUI2 scores. Corresponding scores with HUI3 were 66 (26.5%) and 103 (41.3%) for no or mild disability and 183 (73.5%) and 146 (58.6%) (p < 0.001) for moderate or severe disability at study entry and 6 weeks, respectively. Children with weight gain >10% had significant improvement in overall HUI2 (0.92 vs 0.84; p = 0.049) and HUI3 scores (0.88 vs 0.78; p = 0.010).
conclusionIn severely and moderately malnourished children with cancer, administration of RUTF and weight gain were associated with improved HRQL. Weight gain can improve HRQL in numerous domains and overall.
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