ArticleEuropean radiology2026
Prognostic relevance of contrast extravasation in patients undergoing endovascular embolization of acute bleeding.
Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- CT-derived adrenal-to-spleen ratio as a predictor of massive transfusion and mortality in emergency transcatheter arterial embolization of active bleeding.Emergency radiology · 2026Article
- Explainable Knowledge-Guided Algorithm for Contrast Extravasation Detection on Computed Tomography.IEEE journal of translational engineering in health and medicine · 2026Article
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9 authors.
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Abstract
objectivesContrast extravasation on imaging studies is a clinical surrogate for bleeding severity. However, the prognostic relevance of this imaging sign needs to be evaluated. The aim of this study was to analyze the impact of contrast extravasation defined by computed tomography (CT) and angiography on massive transfusion and 30-day mortality in patients with acute bleeding undergoing transarterial embolization (TAE). MATERIALS AND
methodsA mixed cohort of patients with acute bleeding requiring treatment with TAE between 2018 and 2022 was retrospectively evaluated. All patients underwent triphasic CT to localize the source of bleeding and to calculate extravasation volumes in the arterial and portal venous phases. The bleeding rate k was calculated from the CT images.
resultsA total of 128 patients (79 male, 61.7%) with a mean age of 67.4 years (range 21-95 years) and an all-cause 30-day mortality rate of 34.4% were included in the present analysis. A moderate positive correlation was identified between transfused packed red blood cell units and bleeding rate k (r = 0.33, p < 0.001). However, no correlation was found between transfused packed red blood cell units and arterial and portal venous extravasation volume. In multivariable logistic regression analysis, bleeding rate k was identified as an independent prognostic factor for massive transfusion (OR 25.77, 95% CI 1.35-493.61, p = 0.031, area under the receiver operating characteristic curve (AUROC) of the model: 0.847) and 30-day mortality (OR 25.04, 95% CI 2.29-273.42, p = 0.008, AUROC of the model: 0.781).
conclusionCT-defined bleeding rate, k, is a prognostic factor for massive transfusion and 30-day mortality in patients with acute bleeding undergoing TAE and may be superior to the volume of contrast extravasation volume alone. Further studies are needed to confirm this finding. KEY POINTS: Question Does contrast media extravasation on CT have a prognostic role in patients with acute bleeding? Findings Bleeding rate, k, was identified as an independent prognostic factor for massive transfusion (OR 25.77) and 30-day mortality (OR 25.04). Clinical relevance Diagnostic triphasic CT can be used to provide prognostic information of patients with acute bleeding.
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