Evidence map›Paper›PMID 40913480›Full record

ReviewJournal of primary care & community health

DoxyPEP: Opportunities for Expansion.

En-Ling Wu, Jade Pagkas-Bather, Aniruddha Hazra, Mai T Pho

Abstract readReview
In one paragraph

Review in Journal of primary care & community health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

En-Ling WuDepartment of Medicine, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-5679-6277
Jade Pagkas-BatherDepartment of Medicine, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-1003-3995
Aniruddha HazraDepartment of Medicine, University of Chicago, Chicago, Illinois, USA.
Mai T PhoDepartment of Medicine, University of Chicago, Chicago, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical trials show that doxycycline post-exposure prophylaxis (DoxyPEP) significantly reduces the risk of bacterial sexually transmitted infections (STIs), especially syphilis and chlamydia, in cisgender men who have sex with men and transgender women. Real-world data suggest DoxyPEP may be beneficial for other populations disproportionately affected by STIs. Given the ongoing STI epidemic we recommend discussing DoxyPEP with all eligible patients. We review clinical guidelines and practical considerations surrounding DoxyPEP, highlight areas for future research, and propose strategies for implementation.

Indexed as

Anti-Bacterial AgentsDoxycyclinePost-Exposure ProphylaxisSexually Transmitted DiseasesFemaleHumansMalePractice Guidelines as TopicAnti-Bacterial AgentsDoxycyclinecommunity healthpreventionprimary carerisky sexual behaviorsocial determinants of health

Identifiers

PMID40913480
PMCPMC12414116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.