Evidence map›Paper›PMID 40913475›Full record

ArticleHead & neck2026

Multiparametric Ultrasound for Preoperative Assessment of Parotid Tumors: A Novel Diagnostic Pathway.

Katharina Margherita Wakonig, Markus Herbert Lerchbaumer, Philipp Arens, Heidi Olze, Steffen Dommerich, Thomas Fischer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katharina Margherita WakonigDepartment of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Markus Herbert LerchbaumerDepartment of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Philipp ArensDepartment of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Heidi OlzeDepartment of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Steffen DommerichDepartment of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Thomas FischerDepartment of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Funding

Deutsche Forschungsgemeinschaft WA 5500/1-1
6 · The paper itself

Abstract

backgroundAccurate preoperative differentiation of parotid gland tumors (PGTs) is essential for facial nerve preservation. This study evaluates a novel, real-time multiparametric ultrasound (mpUS) approach combining B-mode, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS), based on qualitative image interpretation.

methodsEighty-nine patients with 91 PGTs underwent mpUS prior to surgery or ultrasound-guided biopsy. Two blinded experts independently reviewed the images and reached consensus through real-time discussion. Only qualitative features were assessed. Histopathology served as the reference.

resultsmpUS achieved 83% sensitivity (95% CI: 62.6-94.0), 94% specificity (95% CI: 84.3-98.1), and 91% accuracy (95% CI: 82.4-96.3). CEUS and SWE provided complementary perfusion and stiffness data. CCDS was excluded due to limited value.

conclusionmpUS improves diagnostic accuracy compared to single-modality US and supports early, targeted treatment. Limitations include the small number of malignancies, single-center design, and qualitative evaluation. Broader use may require training and equipment access.

Indexed as

Parotid NeoplasmsAdultAgedAged, 80 and overContrast MediaElasticity Imaging TechniquesFemaleHumansImage-Guided BiopsyMaleMiddle AgedPreoperative CareSensitivity and SpecificityUltrasonographyYoung AdultContrast Mediacontrast‐enhanced ultrasounddiagnostic accuracymultiparametric ultrasoundparotid gland tumorsreal‐time imagingshear wave elastography

Identifiers

PMID40913475
PMCPMC12797010

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.