ArticleJournal of child psychology and psychiatry, and allied disciplines2026
Subclinical hypomania, psychiatric and neurodevelopmental diagnoses: phenotypic and aetiological overlap.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Childhood trauma and subclinical cin early adulthood: A genetically informative study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
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7 authors.
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Abstract
backgroundSubclinical hypomanic symptoms are fairly common in the general population but are linked to psychiatric and neurodevelopmental conditions. However, the genetic and environmental origins of these associations are unclear. This twin study examined the phenotypic and aetiological associations between subclinical hypomania and psychiatric and neurodevelopmental diagnoses.
methodsParticipants were 4,932 twin pairs from the Child and Adolescent Twin Study in Sweden. Hypomanic symptoms were assessed using the parent-rated Mood Disorders Questionnaire when the twins were aged 18. Specialist diagnoses of 14 conditions and symptoms were ascertained from Swedish population registries. Phenotypic associations between hypomania and these conditions/symptoms were investigated, and their aetiological overlap was examined using the twin method.
resultsSubclinical hypomania was significantly associated with all 14 diagnoses. The highest odds were for psychotic disorders (odds ratio [OR] = 1.48, 95% confidence intervals [CI] = 1.33-1.64, p < .001). The genetic correlations between subclinical hypomania and these diagnoses ranged from 0.12 (95% CI: 0.04-0.33) for eating disorders (other than anorexia) to 0.58 (95% CI: 0.28-1.00) for drug misuse disorders. The nonshared environmental correlations were highest for psychotic disorders (0.52, 95% CI: -0.02 to 0.92) and lowest for body dissatisfaction (0.04, 95% CI: -0.01 to 0.08). For bipolar disorder, psychotic disorders, and attention deficit hyperactivity disorder, genetic, and nonshared environmental correlations with subclinical hypomania were of a similar magnitude.
conclusionsThe association between subclinical hypomania and the diagnosis of multiple psychiatric phenotypes highlights its important role in the developmental pathway to clinical disorders, its complex origins, and that it may represent a quantitative trait for various psychiatric phenotypes.
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