ArticleMolecular genetics & genomic medicine2025
46,XY/46,XY Chimerism: Prenatal Presentation and Postnatal Outcome.
Article in Molecular genetics & genomic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- 46,XY/46,XY Chimerism: Prenatal Presentation and Postnatal Outcome.Molecular genetics & genomic medicine · 2025Article
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7 authors.
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Abstract
backgroundHuman chimerism is rare, and most prevalent with discordant chromosomal sex. We report a male 46,XY/46,XY chimera, born through a spontaneously conceived pregnancy to a healthy 32-year-old G1P0 Indian, African, and Scottish female and her 34-year-old healthy Chinese partner. The prenatal presentation and postnatal outcomes are described.
methodsA prenatal cell-free DNA screening test, amniocentesis with QF-PCR and SNP microarray, and postnatal microarray and FISH study on peripheral blood, placenta, and umbilical cord were used to evaluate chimerism.
resultsThe prenatal cell-free screening test revealed high risk for triploidy/vanishing twin, but there was no confirmation from early ultrasound. Subsequent QF-PCR on amniocytes showed a profile suggestive of a tetragametic chimera. G-banding showed a 46,XY karyotype. A SNP microarray detected two copy number gains of uncertain significance on chromosome 6q, derived from the father who was a balanced carrier of ins(6;11). A postnatal microarray and FISH study confirmed the presence of two cell lines, each with a 46,XY complement but with different submicroscopic structural changes including recombinant and insertion changes. Clinical evaluations of the child at birth and 8 weeks of age were coordinated to detect the presence of chimeric symptoms.
conclusionWith a confirmed incidental finding of 46,XY/46,XY chimerism, we present that underlying same-sex chimerism may be under-recognized.
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