Trial reportOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2025
Response of accommodation and vergence systems to low dose atropine.
Trial report in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dose-Dependent Effects of Atropine on Accommodative and Binocular Visual Function for Myopia Control in Children: A Systematic Review and Meta-Analysis.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Pooled it
- Response of accommodation and vergence systems to low dose atropine.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Trial
- Beyond Dose: Residual Functional Reserve Should Guide Atropine Safety Assessment in Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Authors' Reply: Beyond Dose: Residual Functional Reserve Should Guide Atropine Safety Assessment in Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Ocular Alignment and Strabismus-Related Findings Associated with Low-Dose Atropine for Myopia Control in Children: A Structured Narrative Review.Children (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeFew studies have comprehensively investigated the effect of low dose atropine on the binocular vision system beyond accommodative amplitude. This study examined the effect of 0.05% atropine eye drops on a range of accommodation and vergence parameters across a 10-day period.
methodsTwenty myopic, adult participants (mean age [SD] 22.3 [1.0] years, mean spherical equivalent refraction [SD] -1.9 [1.0] D) were randomised to receive either atropine (0.05% atropine sulphate, n = 10) or control (0.9% sodium chloride, n = 10) eye drops for nightly use for nine consecutive nights. Accommodative posture, monocular and binocular accommodative amplitude (AA), positive and negative relative accommodation (PRA/NRA), binocular accommodative facility (BAF), distance and near heterophoria, positive and negative fusional vergences (PFV/NFV), near point of convergence (NPC) and gradient accommodative convergence to accommodation ratios (AC/A) were measured at baseline, day-3 and day-10.
resultsBy day-10, accommodative lag had increased significantly and AA, PRA and BAF had all decreased significantly in the atropine group, while there were no significant changes in any of the control group measurements. Near heterophoria shifted significantly towards esophoria and the NFV break and recovery points were decreased significantly in the atropine group by day-10. Additionally, NPC reduced by a clinically significant amount (that bordered on statistical significance), with no changes found in the control group. There was no significant change in distance heterophoria, AC/A, NRA or PFV (all p > 0.05) at day-3 or day-10 in either treatment group.
conclusionsAtropine (0.05%) use disrupted accommodation significantly over 10 days and increased convergence at near. While near heterophoria shifted towards esophoria, participants' ability to counteract this was also diminished by a reduction in NFV. This suggests that the near heterophoria and fusional reserves of children using 0.05% atropine for myopia control should be monitored closely.
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