Evidence map›Paper›PMID 40913316›Full record

ArticleBiophysical journal2026

Plectin affects cell viscoelasticity at small and large deformations.

James P Conboy, Mathilde G Lettinga, Nicole van Vliet, Lilli Winter, Gerhard Wiche, Fred C MacKintosh, Gijsje H Koenderink

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James P ConboyDepartment of Bionanoscience and Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, the Netherlands.
Mathilde G LettingaDepartment of Bionanoscience and Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, the Netherlands.
Nicole van VlietDepartment of Bionanoscience and Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, the Netherlands.
Lilli WinterDepartment of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.
Gerhard WicheMax Perutz Laboratories, Department of Biochemistry and Cell Biology, University of Vienna, Vienna, Austria.
Fred C MacKintoshDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas; Center for Theoretical Biological Physics, Rice University, Houston, Texas; Department of Chemistry and Department of Physics & Astronomy, Rice University, Houston, Texas.
Gijsje H KoenderinkDepartment of Bionanoscience and Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, the Netherlands. Electronic address: g.h.koenderink@tudelft.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plectin is a giant protein of the plakin family that cross-links the cytoskeleton of mammalian cells. It is expressed in virtually all tissues, and its dysfunction is associated with various diseases such as skin blistering. There is evidence that plectin regulates the mechanical integrity of the cytoskeleton in diverse cell and tissue types. However, it is unknown how plectin modulates the mechanical response of cells depending on the frequency and amplitude of mechanical loading. Here we demonstrate the role of plectin in the viscoelastic properties of fibroblasts at small and large deformations by quantitative single-cell compression measurements. To identify the importance of plectin, we compared the mechanical properties of wild-type (Plec

Indexed as

ElasticityPlectinActinsAnimalsBiomechanical PhenomenaCytoskeletonFibroblastsMiceStress, MechanicalViscosityActinsPlectin

Identifiers

PMID40913316
PMCPMC12821017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.