Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
27 authors.
Manru ShiDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.ORCID 0009-0001-4934-087X
Quan LinDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Shaohong FangThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0000-0002-7536-0786
Cheng MaHarbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Weiwei XuDepartment of Radiation Therapy Technology Center Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Di SunDepartment of Radiation Therapy Technology Center Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Naixin WangThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0000-0003-3344-0021
Jingxuan CuiThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0009-0000-6798-2270
Zhonghua TongThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0009-0005-3246-8278
Yuwu ChenDepartment of Cardiology The Second Affiliated Hospital of Harbin Medical University Harbin China.ORCID 0009-0001-2156-6965
Xing LuoDepartment of Cardiology The Second Affiliated Hospital of Harbin Medical University Harbin China.
Sining HuThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0000-0002-8680-7045
Tuo HuangThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.
Yunlong HeDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Yang CaoDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Jiayin LiuDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Jiaqi LiDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Anxin GuDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Xiuwen LanThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.
Meng ChiThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0000-0001-5650-9779
Chao WangThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0000-0003-3518-7680
Jiaqi GuDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Siqi TianDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Jiaao LiuDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Zixuan LiuDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.
Maomao ZhangThe Key Laboratory of Myocardial Ischemia Harbin Medical University, Ministry of Education Harbin Heilongjiang Province China.ORCID 0000-0001-5649-7931
Mingyan EDepartment of Radiation Oncology Harbin Medical University Cancer Hospital Harbin Heilongjiang Province China.ORCID 0000-0001-6592-9062
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundCardiac issues following radiotherapy are increasingly prevalent among patients with thoracic cancer and coronary disease. However, the mechanisms underlying radiotherapy-induced plaque instability and changes in plaque characteristics on imaging remain unclear. This study used single-cell RNA sequencing to identify key features of vulnerable plaques following radiotherapy.
methodsWe applied dual-mode synchronized optical coherence tomography-intravascular ultrasound imaging in a rabbit model to reveal the characteristics of vulnerable plaques at various time points postradiotherapy. We then conducted single-cell RNA sequencing on atherosclerotic lesions from
resultsIn vivo optical coherence tomography-intravascular ultrasound imaging at the initial stage accurately evaluated radiation exposure's effect on the stability of rabbit carotid plaques. High-throughput single-cell transcriptomics mapped the radiotherapy-induced immune system remodeling in atherosclerotic lesions, and identified a granzyme K
conclusionsWe identified characteristic arterial imaging changes resulting from radiation injury, accurately and dynamically assessing the effects of radiation exposure on plaque stability. Radiation exposure affected plaque stability by modulating GZMK
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Single-Cell RNA Sequencing Reveals Granzyme K · full record | OpenQuestion