Evidence map›Paper›PMID 40913204›Full record

ArticleSocial psychiatry and psychiatric epidemiology2026

Food insecurity and postnatal depression: the mediating effect of perceived social support among women in Khayelitsha, South Africa.

S Mathew, C Lund, N Seward

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Article in Social psychiatry and psychiatric epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

S MathewDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. mathew.susan555@gmail.com.ORCID http://orcid.org/0009-0009-3790-3274
C LundCentre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5159-8220
N SewardCentre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-4821-9437

Funding

Shared Research Project ComponentU19MH095699 · NIMH · UNIVERSITY OF CAPE TOWN · PI ALEM, ATALAY, LUND, CRICK · 2011 to 2015
$2.6M
NIMH NIH HHS U19MH095699
6 · The paper itself

Abstract

purposeUnderstanding the mechanisms through which poverty influences perinatal depression can provide insight into how to develop interventions to improve maternal mental health. To address this question, we aim to estimate indirect effects of important mediators on the causal relationship between food insecurity and symptoms of postnatal depression.

methodsWe used data from the control arm of the Africa Focus on Intervention Research for Mental health - South Africa (AFFIRM-SA) trial that included pregnant women with perinatal depression. Interventional effects (used for models that may have multiple correlated mediators) were used to decompose the total effect of food insecurity captured at baseline on symptoms of perinatal depression reducing by at least 40% (using the 17-item HDRS instrument - yes/no) at three months after delivery of the baby, into the following indirect effects: number of antenatal visits attended; suicidality at eight months gestation; and levels of social support captured at eight months gestation using the Multidimensional Scale of Perceived Social Support.

resultsFood insecurity was associated with a 15% reduced probability of symptoms of depression improving at three months post-delivery (-0·151, bias-corrected 95% CI: - 0.267, -0·032), of which 48% was mediated through reduced levels of social support in women exposed to food insecurity (-0.073: bias-corrected 95% CI: -0.146, -0.029). There was no conclusive evidence to support the mediating effects of attending antenatal visits and suicidality.

conclusionsOur findings suggest that providing social support can help to reduce symptoms of postnatal depression. Future research should explore developing and evaluating a package of care for pregnant women with perinatal depression that improves food security and levels of social support. This research suggests that policy makers and practitioners have a renewed focus on increasing social support systems for women during the perinatal period, especially in cases of food insecurity.

Indexed as

Depression, PostpartumFood InsecurityFood SupplyPovertySocial SupportAdultFemaleHumansPregnancySouth AfricaYoung AdultFood insecurityInterventional effectsMediationPostnatal depressionSocial causationSocial support

Identifiers

PMID40913204
PMCPMC12948881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.