Evidence map›Paper›PMID 40913178›Full record

ArticleSurgical endoscopy2025

Quantitative blood perfusion assessment by the SPY-QP software program for minimally invasive rectal cancer surgery.

Chie Hagiwara, Jun Watanabe, Yusuke Suwa, I Shoichiro, Norikazu Yamada, Yuto Igarashi, Toshinori Kobayashi, Yoshihiro Mori

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chie HagiwaraDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Jun WatanabeDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan. watanabj@hirakata.kmu.ac.jp.ORCID http://orcid.org/0000-0002-7187-3664
Yusuke SuwaDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
I ShoichiroDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Norikazu YamadaDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Yuto IgarashiDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Toshinori KobayashiDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Yoshihiro MoriDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka, 573-1010, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the usefulness of indocyanine green fluorescence imaging (ICG-FI) for anastomotic perfusion has been demonstrated in randomized controlled trials, the incidence of anastomotic leakage is not sufficiently low, even in patients using ICG. Because blood flow assessment using ICG is not completely objective, the objectivity of blood flow evaluation is expected to improve by quantification of fluorescence signals. This study aimed to clarify the efficacy of quantitative assessment of blood flow using ICG-FI with the SPY-QP software program in rectal cancer surgery.

methodsThis retrospective study included 201 patients with rectal cancer who underwent laparoscopic or robotic surgery for rectal cancer using SPY-QP at two tertiary referral centers between December 2021 and November 2024. We recorded the time from the onset of fluorescence at the most proximal bowel wall to the plateau (Tmax) and the relative fluorescence intensity and assessed its correlation with the occurrence of AL.

resultsAmong 201 patients, anastomotic leakage occurred in 6 patients (3.0%). Tmax in the SPY-QP was positively correlated with the time for fluorescence perfusion after ICG injection (correlation coefficient = 0.55). The point of the proximal colon transection line was shifted by quantification of ICG-FI in 17 patients (8.5%). Of these, 6 patients (3.0%) with a decrease in relative fluorescence intensity of the planned transection line could not be assessed by a qualitative assessment of ICG-FI. The relative fluorescence intensities of patients without anastomotic leakage were ≥ 60% for Tmax ≤ 30 s and ≥ 70% for Tmax 31-40 s.

conclusionsSPY-QP software could provide a more objective assessment of anastomotic perfusion using ICG-FI.

Indexed as

Anastomotic LeakLaparoscopyOptical ImagingRectal NeoplasmsRobotic Surgical ProceduresSoftwareAgedAged, 80 and overAnastomosis, SurgicalFemaleHumansIndocyanine GreenMaleMiddle AgedRetrospective StudiesIndocyanine GreenAnastomotic leakageBlood perfusionIndocyanine greenQuantitative assessmentRectal cancer

Identifiers

PMID40913178

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.