Evidence map›Paper›PMID 40913146›Full record

ArticlePsychopharmacology2026

Short-term residual effects of smoked cannabis on simulated driving performance.

Kyle F Mastropietro, Jake A Rattigan, Anya Umlauf, David J Grelotti, Marilyn A Huestis, Raymond T Suhandynata, Igor Grant, Robert L Fitzgerald, Thomas D Marcotte

Abstract read
In one paragraph

Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyle F MastropietroSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Jake A RattiganSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Anya UmlaufCenter for Medicinal Cannabis Research, Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
David J GrelottiCenter for Medicinal Cannabis Research, Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Marilyn A HuestisInstitute for Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.
Raymond T SuhandynataCenter for Medicinal Cannabis Research, Department of Pathology, University of California San Diego, San Diego, CA, USA.
Igor GrantCenter for Medicinal Cannabis Research, Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Robert L FitzgeraldCenter for Medicinal Cannabis Research, Department of Pathology, University of California San Diego, San Diego, CA, USA.
Thomas D MarcotteCenter for Medicinal Cannabis Research, Department of Psychiatry, University of California San Diego, San Diego, CA, USA. tmarcotte@ucsd.edu.ORCID http://orcid.org/0000-0002-3039-6400

Funding

Alcohol Research in the Science/Practitioner ModelT32AA013525 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY, ANDREA SPADONI TOWNSEND · 2002 to 2026
$8.4M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
NIAAA NIH HHS T32 AA013525NIDA NIH HHS T32 DA031098State of California Assembly Bill 266 (Bonta/Cooley/Jones-Sawyer/Lackey: Agreement #907).
6 · The paper itself

Abstract

rationaleBetween periods of use, chronic cannabis consumers may display residual effects on selective cognitive functions, particularly memory and attention. Whether there are comparable deficits in real-world behaviors, such as driving, has not been thoroughly examined.

objectivesThe current study explored the association between driving simulator performance, cannabis use history, and demographic factors after ≥ 48 h of abstinence. Study I examined simulator performance across a broad range of use within 191 healthy cannabis users. Study II compared performance between participants with the highest cannabis use intensity and a non-cannabis-using comparison group.

methodsIn Study I, 191 healthy cannabis users completed a 25-minute simulated drive, following ≥ 48 h of abstinence. In Study II, a pilot study comprising a subset of 18 frequent cannabis users was compared to 12 non-using controls who completed identical driving measures in a separate study. In both studies, the main outcome was the Composite Drive Score (CDS), a global measure of driving performance comprising key driving-related variables, including standard deviation of lateral position.

resultsIn Study I, there was no relationship between CDS, its subtests, measures of cannabis use history, or demographic variables (all ps > 0.10). In Study II, frequent cannabis users and the non-using comparison group did not differ on CDS or performance on its subtests (all ps > 0.40).

conclusionsThe current study did not find evidence of a residual effect of cannabis on simulated driving performance during a short period of cannabis abstinence. Future studies would benefit from inclusion of larger non-cannabis-using comparison groups.

Indexed as

Automobile DrivingMarijuana SmokingPsychomotor PerformanceAdolescentAdultAttentionCannabisComputer SimulationFemaleHumansMaleMiddle AgedPilot ProjectsTime FactorsYoung AdultCannabisDrivingMarijuanaResidual effects

Identifiers

PMID40913146
PMCPMC12478537

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.