ArticleEye (London, England)2025
Association between atrial fibrillation and age-related macular degeneration: A nationwide cohort study.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Evaluation of serum semaphorin-3A and interleukin 6 levels in patients with neovascular age-related macular degeneration.BMC ophthalmology · 2026Article
- An association between atrial fibrillation and age-related macular degeneration: looking beyond mere coincidence.Eye (London, England) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
BACKGROUND/
objectivesAtrial fibrillation (AF) and age-related macular degeneration (AMD) are common debilitating conditions that share pathomechanisms involving chronic inflammation and oxidative stress. However, the association between AMD and AF, which is important for comprehending the pathogenesis, referral, and treatment strategies of these diseases, remains unknown. SUBJECTS/
methodsThis nationwide population-based retrospective cohort study used claims data from the National Health Insurance Research Database of Taiwan. From 1 January 2003 to 31 December 2018, an AF and AMD cohort of 34,236 and 31,766 patients, respectively, along with their matched control cohorts, were constructed using stabilised inverse probability of treatment weighting. The primary outcomes were the incidence of AMD following newly diagnosed AF and the incidence of AF following newly diagnosed AMD. A Cox regression model was used to estimate hazard ratios (HR) for these outcomes. Subgroup analysis based on AMD subtype and stratified analyses by age and sex were also conducted.
resultsCompared with controls, patients with AF had a significantly increased risk of developing AMD (HR 1.10; 95% confidence interval [CI] 1.04-1.17). Similarly, patients with AMD had a significantly increased risk of developing AF (HR 1.08; 95%CI 1.02-1.15). Further subgroup analysis revealed a reciprocal association between AF and dry AMD. Age- and sex-stratified analyses demonstrated increasing risk trends for AF and AMD.
conclusionsAF and AMD may share common underlying risk factors and pathophysiological mechanisms. Our findings identified a reciprocal association between AF and AMD. Further research is warranted to elucidate the pathophysiology of AF and AMD.
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