Evidence map›Paper›PMID 40913074›Full record

SynthesisEye (London, England)2025

Antibiotic exposure and drug-induced intracranial hypertension: a systematic review and meta-analysis.

Brendan K Tao, Kate Lim, Jiwon Hwang, Aljeena Rahat Qureshi, Thanansayan Dhivagaran, Fahad Butt, Jim S Xie, Jonathan A Micieli, Edward A Margolin

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brendan K TaoDepartment of Ophthalmology & Vision Science, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-7069-3162
Kate LimFaculty of Medicine, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0009-0000-1675-9933
Jiwon HwangFaculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Aljeena Rahat QureshiTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-9462-6482
Thanansayan DhivagaranFaculty of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
Fahad ButtFaculty of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
Jim S XieDepartment of Ophthalmology & Vision Science, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-5014-561X
Jonathan A MicieliDepartment of Ophthalmology & Vision Science, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-4911-9152
Edward A MargolinDepartment of Ophthalmology & Vision Science, University of Toronto, Toronto, ON, Canada. Edward.Margolin@uhn.ca.ORCID http://orcid.org/0000-0002-6738-7225

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesDrug-induced intracranial hypertension (DIH) is a rare condition that has been associated with several risk factors, including exposure to certain medications. Herein, we synthesised the literature-pooled quantitative risk of developing DIH with antibiotics use. SUBJECTS/

methodsMedline, Embase, and Cochrane Library were searched (inception to June 2024). We included observational or randomised studies reporting the incidence of antibiotic-related DIH, or the comparative odds of DIH between antibiotic users and non-users. Risk of bias was assessed via the ROBINS-E tool. Non-pairwise and pairwise meta-analyses (with random effects) were conducted to determine the pooled incidence of antibiotic-related DIH and the comparative odds of DIH among antibiotic users and non-users, respectively.

resultsWe identified 10 studies (all observational studies). Overall, tetracycline class antibiotics were significantly associated with DIH in both least- (3.96, 95%CI [1.33, 11.78], p = 0.013, I

conclusionsDespite unclear pathophysiology, low certainty evidence supports that tetracycline and quinolone class antibiotics are associated with DIH. Dose-response studies are needed to support causality.

Indexed as

Anti-Bacterial AgentsIntracranial HypertensionHumansIncidenceObservational Studies as TopicRisk FactorsAnti-Bacterial Agents

Identifiers

PMID40913074
PMCPMC12494680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.