ArticleNature communications2025
Ultrasound system for precise neuromodulation of human deep brain circuits.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuromodulation of the central nervous system for facial pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Editorial: From causal circuit mapping to clinical translation: Prefronto-thalamic hypoconnectivity in schizophrenia.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Neurostimulation in the treatment of psychiatric disorders: Underlying mechanisms and critical analysis of circuit-based interventions.Molecular psychiatry · 2026Review
- A new in silico model to precisely design focused ultrasound brain therapies.Medical physics · 2026Article
- TRPC4/TRPC5 are critical for neuronal modulation by transcranial focused ultrasound in retrosplenial cortex in male mice.Nature communications · 2026Article
- Bayesian-enhanced closed-loop optimization of ultrasound protocols for targeted and precise neuromodulation.bioRxiv : the preprint server for biology · 2026Article
- Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation.Nature communications · 2026Article
- Imaging of Neurovascular Activity during Motor Responses Evoked by Displacement-guided Focused Ultrasound (DgFUS) Neuromodulation in Mice.Research square · 2026Article
- REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems.Current biology : CB · 2026Review
- The human amygdala in threat learning and extinction.Science advances · 2026Article
- Low-Intensity Focused Ultrasound Neuromodulation in Psychiatric Disorders: Mechanisms, Models, and Missing Links.Biological psychiatry · 2026Review
- In vivo acoustoelectric neural recording in mice enabled by ultrasound-induced frequency mixing.Communications engineering · 2026Article
- Dynamic Exploration of Resting-State Brain Attractors Altered in Major Depressive Disorder.Entropy (Basel, Switzerland) · 2026Article
- Ultrasound modulates microglial activity and reduces neuroinflammation in a parameter-dependent manner.NPJ acoustics · 2026Article
- Islands of Inference: A Neurodevelopmental Architecture for Fixed Delusions.Psychopathology · 2026Review
- Ultrasound Brain-Computer Interfaces for Transcranial Closed-Loop Neuromodulation.BME frontiers · 2026Article
- Flexible ultrasound array for subcortical brain stimulation in humans: a simulation study.NPJ acoustics · 2026Article
- Translational prospectives for deep brain stimulation and low-intensity focused ultrasound neuromodulation: IFCN Handbook chapter.Clinical neurophysiology practice · 2026Review
- Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity.Nature communications · 2025Article
- Ultrasonic rewarming of cryopreserved alginate encapsulated liver spheroids.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We introduce an advanced transcranial ultrasound stimulation (TUS) system for precise deep brain neuromodulation, featuring a 256-element helmet-shaped transducer array (555 kHz), stereotactic positioning, individualised planning, and real-time fMRI monitoring. Experiments demonstrated selective modulation of the lateral geniculate nucleus (LGN) and connected visual cortex regions. Participants showed significantly increased visual cortex activity during concurrent TUS and visual stimulation, with high cross-individual reproducibility. A theta-burst TUS protocol produced robust neuromodulatory effects, decreasing visual cortex activity for at least 40 min post-stimulation. Control experiments confirmed these effects were specific to the targeted LGN. Our findings reveal this system's potential to non-invasively modulate deep brain circuits with unprecedented precision and specificity, offering new avenues for studying brain function and developing targeted therapies for neurological and psychiatric disorders, with transformative potential for both research and clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.