Evidence map›Paper›PMID 40912898›Full record

ArticleJournal of neurophysiology2025

Minimal changes in excitation-contraction coupling in spastic human muscle.

Zheng Wang, Ernest M Hoffman, William J Litchy, Alexander Y Shin, Peter C Rhee, Kenton R Kaufman, Richard L Lieber

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zheng WangDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0009-0000-5504-1449
Ernest M HoffmanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-7293-8290
William J LitchyDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-0483-442X
Alexander Y ShinDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, United States.
Peter C RheeDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-0530-4225
Kenton R KaufmanDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7311-3781
Richard L LieberShirley Ryan AbilityLab, Chicago, Illinois, United States.ORCID 0000-0002-7203-4520

Funding

RRD VA I01 RX002462RRD VA IK6 RX003351
6 · The paper itself

Abstract

Spasticity results from upper motor neuron lesions and can create a deforming force and pain, and is often accompanied by contracture. Although the origin of spasticity is neural, there is ample evidence of secondary muscle changes. Here, we use direct measurement of the force-frequency relationship (FFR) to characterize human muscle's physiological properties. This study directly quantified the FFR of both healthy and spastic human skeletal muscles. Muscle force was measured intraoperatively in healthy gracilis (

Indexed as

Excitation Contraction CouplingMuscle ContractionMuscle, SkeletalMuscle SpasticityAdultAgedFemaleHumansMaleMiddle Agedcalcium kineticsforce-frequency relationshiphuman skeletal musclespasticitytwitch contraction kinetics

Identifiers

PMID40912898
PMCPMC12569795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.