Evidence map›Paper›PMID 40912886›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Persistence of cardiac malprogramming in late gestational fetal sheep by early to midgestational testosterone excess.

Bashar Alkhatib, Divya Purswani, Alekya Dantam, Md Rahatullah Razan, Mary Jabari, Vasantha Padmanabhan, Arpita Kalla Vyas

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bashar AlkhatibDepartment of Pediatrics, Washington University, St. Louis, Missouri, United States.ORCID 0000-0002-3001-4337
Divya PurswaniDepartment of Pediatrics, Washington University, St. Louis, Missouri, United States.
Alekya DantamDepartment of Pediatrics, Washington University, St. Louis, Missouri, United States.
Md Rahatullah RazanDepartment of Pediatrics, Washington University, St. Louis, Missouri, United States.ORCID 0000-0002-6999-5224
Mary JabariDepartment of Pediatrics, Washington University, St. Louis, Missouri, United States.
Vasantha PadmanabhanDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-8443-7212
Arpita Kalla VyasDepartment of Pediatrics, Washington University, St. Louis, Missouri, United States.ORCID 0000-0002-6227-7457

Funding

Gestational Hyperandrogenism in Cardiovascular ProgrammingR01HL139639 · NHLBI · WASHINGTON UNIVERSITY · PI PADMANABHAN, VASANTHA, VYAS, ARPITA · 2020 to 2023
$2.7M
Assessment of Placental Blood Volume Flow and Function in IUGR Using a Transfer Function ModelR21HD095501 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUBIN, JONATHAN M · 2019 to 2020
$448k
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD095501HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL 139639NHLBI NIH HHS R01 HL139639NICHD NIH HHS R21 HD095501
6 · The paper itself

Abstract

Excess testosterone (T) exposure from early to midgestation (

Indexed as

Fetal HeartHeart VentriclesTestosteroneTestosterone PropionateVentricular RemodelingAnimalsApoptosisCyclin D1FemaleGestational AgeMaleMyocytes, CardiacPregnancyProto-Oncogene Proteins c-aktSex FactorsSheepCyclin D1Proto-Oncogene Proteins c-aktTestosteroneTestosterone Propionatecardiovascular diseasefetal programminghyperandrogenism

Identifiers

PMID40912886
PMCPMC12463318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.