ArticleJACC. Case reports2025
Concurrent TTR and AL Amyloidosis: Diagnostic Challenges and Clinical Implications.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multimodality Imaging in Monoclonal Gammopathy of Undetermined Significance and ATTR Wild-Type Cardiac Amyloidosis.Life (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmyloidosis is a disorder characterized by misfolded protein deposits in organs, often manifesting as cardiac disease. CASE SUMMARY: A 60-year-old male with a history of isolated proteinuria and recent fat biopsy-proven transthyretin (TTR) amyloidosis was referred to us for evaluation of cardiac involvement with amyloidosis. He underwent a technetium pyrophosphate scan which showed Perugini grade 3 uptake concerning for cardiac involvement. His persistent proteinuria and serum IgG kappa monoclonal protein raised suspicion for light-chain (AL) amyloidosis. Endomyocardial biopsy confirmed TTR cardiac amyloidosis, while a subsequent kidney biopsy and bone marrow evaluation revealed renal-limited AL kappa amyloidosis. DISCUSSION: This rare presentation highlights the challenge of distinguishing between TTR and AL amyloidosis, especially with atypical features. It underscores the necessity for tissue diagnosis and mass spectrometry in complex cases, even with seemingly concordant noninvasive findings.
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