Evidence map›Paper›PMID 40912834›Full record

ArticleJACC. Case reports2025

Resolution of Severe Thrombocytopenia and Candida parapsilosis Infective Endocarditis With Fourth Open-Heart Surgery.

Ayaka Ino, Taku Omori, Ryosai Inoue, Hirokazu Toyoshima, Katsuyuki Tone, Naoki Fujimoto, Tetsuya Seko, Toshiya Tokui, Atsunobu Kasai, Kaoru Dohi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ayaka InoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan; Department of Cardiology, Ise Red Cross Hospital, Ise, Japan.
Taku OmoriDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. Electronic address: omori-t@med.mie-u.ac.jp.
Ryosai InoueDepartment of Thoracic Surgery, Ise Red Cross Hospital, Ise, Japan.
Hirokazu ToyoshimaDepartment of Infectious Diseases, Ise Red Cross Hospital, Ise, Japan.
Katsuyuki ToneDepartment of Cardiology, Ise Red Cross Hospital, Ise, Japan.
Naoki FujimotoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.
Tetsuya SekoDepartment of Cardiology, Ise Red Cross Hospital, Ise, Japan.
Toshiya TokuiDepartment of Thoracic Surgery, Ise Red Cross Hospital, Ise, Japan.
Atsunobu KasaiDepartment of Cardiology, Ise Red Cross Hospital, Ise, Japan.
Kaoru DohiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical treatment for infective endocarditis (IE) with severe thrombocytopenia is considered high risk and is often avoided. CASE SUMMARY: A 67-year-old man with a history of 3 open-heart surgeries presented with fever and severe thrombocytopenia accompanied by a bleeding tendency. Blood cultures and transthoracic echocardiography confirmed IE of the aortic bioprosthetic valve caused by Candida parapsilosis. Despite appropriate antifungal medical therapy, blood cultures remained persistently positive, severe thrombocytopenia persisted, and the vegetation continued to enlarge, resulting in medially refractory IE. Surgical intervention was deemed essential, and the patient underwent a fourth open-heart surgery. Shortly after the procedure, blood cultures turned negative, and platelet counts improved dramatically. The patient was discharged home. DISCUSSION: Severe thrombocytopenia in this case was likely caused by the fungal infection and vegetation formation. TAKE-HOME MESSAGE: Surgical treatment for medically refractory fungal IE can aid in infection control and result in significant improvement in platelet count.

Indexed as

Candida parapsilosisinfective endocarditisthrombocytopenia

Identifiers

PMID40912834
PMCPMC12426664

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