Evidence map›Paper›PMID 40912688›Full record

ArticleInflammatory bowel diseases2026

The Impact of Sarcopenia on Clinical Outcomes in Pediatric Crohn's Disease.

Giulia D'Arcangelo, Delia De Mitri, Ludovica Busato, Lorenza Bottino, Francesca Maccioni, Andrea Verrino, Marina Aloi

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Article in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Giulia D'ArcangeloPediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy.
Delia De MitriPediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy.
Ludovica BusatoDepartment of Radiology, Sapienza University of Rome, Rome, Italy.
Lorenza BottinoDepartment of Radiology, Sapienza University of Rome, Rome, Italy.
Francesca MaccioniDepartment of Radiology, Sapienza University of Rome, Rome, Italy.
Andrea VerrinoPediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy.
Marina AloiPediatric Gastroenterology, Hepatology and Cystic Fibrosis Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.ORCID 0000-0001-7404-4004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effect of sarcopenia on clinical outcomes in children with Crohn's disease (CD) is unknown. We investigated whether sarcopenia at the diagnosis impacts the outcomes of children with CD.

methodsThis was a retrospective, single-center, case-control study of newly diagnosed children with CD undergoing magnetic resonance (MR) within 1 month from the diagnosis, from 2011 to 2022. Sarcopenia was assessed by measuring total psoas muscle area (tPMA) at L3-L4 level on the MR and defined as z-score values ≤2 SDs. Children with and without sarcopenia were compared for the risk of disease flares, CD-related hospitalization, complications, need for step-up treatment, and courses of steroids over a 2-year follow-up.

resultsSeventy-eight children were included (median age 10.7 years), 46 (59%) with sarcopenia and 32 (41%) without. The risk of clinical relapse was higher in patients with sarcopenia at 6 [19.5% vs 3%, odds ratio (OR) 7.5 (95% CI, 1.5-85)] and 12 months [30% vs 6%, OR 6.5 (95% CI, 1.4-30.4)]. Kaplan-Meier analysis showed lower survival free from relapses in children with sarcopenia (log rank P = .01, hazard ratio 2.7, 95% CI, 1.4-4.5). Multivariate analysis identified sarcopenia as independent predictors of clinical relapses (OR 1.7, 95% CI, 1-3.1, P = .045). No other independent predictor of unfavorable outcome was detected.

conclusionsThe presence of sarcopenia at the diagnosis increases the risk of clinical relapses in the first year of diagnosis. Magnetic resonance evaluation of the tPMA could therefore help identify children at higher risk of worse outcomes.

Indexed as

Crohn DiseaseSarcopeniaAdolescentCase-Control StudiesChildFemaleFollow-Up StudiesHospitalizationHumansKaplan-Meier EstimateMagnetic Resonance ImagingMalePrognosisPsoas MusclesRecurrenceRetrospective Studiesbody compositionchildrenCrohn's diseasemuscle mass

Identifiers

PMID40912688
PMCPMC12759052

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