Evidence map›Paper›PMID 40912401›Full record

ArticleOphthalmology. Glaucoma

Widefield OCT Angiography and Euclidian Distance Analysis of Microvascular Deficits in Glaucomatous Eyes.

Diogo F Muller, Yingying Shi, Maria J Chaves-Samaniego, Khushali Shah, Gustavo Rosa Gameiro, Giovanni Gregori, Steven J Gedde, Luis E Vazquez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Diogo F MullerDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Yingying ShiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Maria J Chaves-SamaniegoDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Khushali ShahDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Gustavo Rosa GameiroDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Giovanni GregoriDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Steven J GeddeDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Luis E VazquezDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: LVazquez@med.miami.edu.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
NEI NIH HHS P30 EY014801
6 · The paper itself

Abstract

purposeTo evaluate superficial microvascular deficits of glaucomatous eyes with widefield OCT angiography (OCTA) and Euclidian distance (ED) analysis.

designCross-sectional study. SUBJECTS: Swept-source OCTA (SS-OCTA) images of healthy and glaucomatous eyes.

methodsTwelve-by-twelve mm scans of healthy and glaucomatous eyes were acquired with SS-OCTA (PLEX Elite 9000, ZEISS). The en face images of the superficial retina segmentation were exported and analyzed with ImageJ software. A fixed threshold that predicted the size of the foveal avascular zone was used to generate binarized images with vascular (white) or deficient (black) pixels. Four vascular parameters were measured within a macula-centered 9 × 10.8 mm ellipse: vascular density (VD), average ED (ED

main outcome measuresVascular density, ED

conclusionsVascular density, ED, and NPD were worse in glaucomatous compared to healthy eyes throughout the widefield OCTA image. High ED and NPD values accentuate regions of inadequate perfusion. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Fluorescein AngiographyGlaucomaIntraocular PressureMicrovesselsOptic DiskRetinal VesselsTomography, Optical CoherenceVisual FieldsAdultAgedCross-Sectional StudiesFemaleFundus OculiHumansMaleMiddle AgedGlaucomaOCT angiography (OCTA)RNFLVessel densityWide-field

Identifiers

PMID40912401
PMCPMC12588040

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.