Evidence map›Paper›PMID 40912204›Full record

ArticleStem cell research2025

Generation of an induced pluripotent stem cell line, JHUi008-A, from a healthy female donor.

Christianne J Chua, Deborah DiSilvestre, Rosy Joshi-Mukherjee, Leslie Tung, Gordon F Tomaselli, Kenneth R Boheler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christianne J ChuaDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Deborah DiSilvestreDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Rosy Joshi-MukherjeeDepartment of Pharmaceutical Sciences, School of Pharmacy, Notre Dame of Maryland University, Baltimore, MD 21210, USA.
Leslie TungDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Gordon F TomaselliDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Kenneth R BohelerDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: kbohele1@jh.edu.

Funding

ARVD/C Dysfunction in Human Stem Cell-Derived Cardiac TissueR01HL120959 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TUNG, LESLIE · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL120959
6 · The paper itself

Abstract

The use of well characterized human induced pluripotent stem cells (hiPSCs) is essential for developmental studies and disease modeling. Here, we report the generation of a normal, female line of hiPSCs following reprogramming of peripheral blood mononuclear cells (PBMCs) derived from a healthy female donor using Sendai virus technology. This line, which has been extensively employed for the in vitro study of mesoderm-derived cardiomyocytes, is available and registered in the Human Pluripotent Stem Cell Registry (hPSCreg). It exhibits a normal karyotype, expresses stemness markers, and demonstrates robust trilineage differentiation potential.

Indexed as

Induced Pluripotent Stem CellsCell DifferentiationCell LineCellular ReprogrammingFemaleHumansKaryotypeLeukocytes, MononuclearTissue Donors

Identifiers

PMID40912204
PMCPMC12577484

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.