Evidence map›Paper›PMID 40911847›Full record

ArticleGut microbes2025

A new gut pathogenic bacteria and its metabolites promote colorectal cancer development and act as non-invasive early diagnostic biomarkers.

Rui Zhang, Mingxiao Li, Hui Tan, Jianyao Liu, Lu Wang, Wenling Dai, Zhimin Fan, Jihua Liu

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
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  4. Crosstalk between mFrontiers in immunology · 2026
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui ZhangJiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Mingxiao LiJiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Hui TanJiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Jianyao LiuJiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Lu WangJiangsu Clinical Innovation Center for Anorectal Diseases of T.C.M, Nanjing Hospital of Chinese Medicine, Nanjing, China.
Wenling DaiJiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Zhimin FanJiangsu Clinical Innovation Center for Anorectal Diseases of T.C.M, Nanjing Hospital of Chinese Medicine, Nanjing, China.
Jihua LiuJiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.ORCID 0000-0002-5769-9989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota dysbiosis is strongly linked to colorectal cancer (CRC), but reliable early diagnostic markers remain elusive. This study investigates the role of a novel

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeShigella flexneriAnimalsBacteriaBiomarkers, TumorEarly Detection of CancerFecesFemaleHumansMaleMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktBiomarkers, TumorPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktColorectal cancerdiagnostic markerDNA damageinflammatory bowel diseaseintestinal bacteriametabolite

Identifiers

PMID40911847
PMCPMC12416176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.