Evidence map›Paper›PMID 40911795›Full record

ArticleThe Journal of physiology2025

Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2-dependent manner.

Brian Lam, Manpreet Gulri, Sokaina Akhtar, Pierre Lemieux, Monica Tawadrous, Mayoorey Murugathasan, Ali A Abdul-Sater, Emilie Roudier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian LamAngiogenesis Research Group, School of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.
Manpreet GulriAngiogenesis Research Group, School of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.
Sokaina AkhtarAngiogenesis Research Group, School of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.ORCID 0009-0001-9390-7853
Pierre LemieuxAngiogenesis Research Group, School of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.
Monica TawadrousAngiogenesis Research Group, School of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.ORCID 0009-0005-8184-9608
Mayoorey MurugathasanSchool of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.
Ali A Abdul-SaterSchool of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.
Emilie RoudierAngiogenesis Research Group, School of Kinesiology and Health Science and the Muscle Health Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada.ORCID 0000-0003-1014-6620

Funding

Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2020-07142DG
6 · The paper itself

Abstract

At the onset of training, each exercise session transiently shifts the distribution of histone post-transcriptional modifications (HPTMs) to activate genes that drive muscle adaptations. The resulting cyclic changes in gene expression promote the acquisition of high oxidative capacities and gains in capillaries. If training stops or remains at the same intensity, adaptation ceases. Whether silencing HPTMs helps to halt adaptation remains understudied. The E3 ubiquitin ligase murine double minute (MDM2) and enhancer of zester homolog 2 (EZH2) interact and tri-methylate histone H3 on lysine 27 (H3K27

Indexed as

HistonesMuscle, SkeletalPhysical Conditioning, AnimalPhysical EnduranceProto-Oncogene Proteins c-mdm2Receptor, Notch1AnimalsEnhancer of Zeste Homolog 2 ProteinMaleMiceMice, Inbred C57BLUbiquitinationUp-RegulationEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHistonesMdm2 protein, mouseNotch1 protein, mouseProto-Oncogene Proteins c-mdm2Receptor, Notch1angiogenesisepigeneticsexercise physiologygene expressionhistone modificationsmurine double minute 2muscle adaptation

Identifiers

PMID40911795
PMCPMC12487604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.