Evidence map›Paper›PMID 40911683›Full record

ArticleScience advances2025

AI-powered automated model construction for patient-specific CFD simulations of aortic flows.

Pan Du, Delin An, Chaoli Wang, Jian-Xun Wang

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. DIRECT MEDICAL IMAGE TO SIMULATION USING AUTO-SEGMENTATION AND POINT CLOUD-BASED CFD.Advances in computational science and engineering · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pan DuDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0001-5445-1497
Delin AnDepartment of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0002-7945-0201
Chaoli WangDepartment of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0002-0859-3619
Jian-Xun WangDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0002-9030-1733

Funding

SCH: Efficient Image-based Hemodynamic Modeling via Physics-integrated Bayesian Deep LearningR01HL177814 · NHLBI · UNIVERSITY OF NOTRE DAME · PI Jian-Xun Wang · 2024 to 2026
$888k
NHLBI NIH HHS R01 HL177814
6 · The paper itself

Abstract

Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and time-consuming, limiting their clinical applications. This study introduces a deep-learning framework that automates the creation of simulation-ready vascular models from medical images. The framework integrates a segmentation module for accurate voxel-based vessel delineation with a surface deformation module that performs anatomically consistent and unsupervised surface refinements guided by medical image data. The integrated pipeline addresses key limitations of existing methods, enhancing geometric accuracy and computational efficiency. Evaluated on public datasets, it achieves state-of-the-art segmentation performance while substantially reducing manual effort and processing time. The resulting vascular models exhibit anatomically accurate and visually realistic geometries, effectively capturing both primary vessels and intricate branching patterns. In conclusion, this work advances the scalability and reliability of image-based computational modeling, facilitating broader applications in clinical and research settings.

Indexed as

AortaModels, CardiovascularPatient-Specific ModelingComputer SimulationDeep LearningHemodynamicsHumans

Identifiers

PMID40911683
PMCPMC12412661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.