Evidence map›Paper›PMID 40911672›Full record

ArticleScience advances2025

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters.

Manon Lang, Stéphane Renard, Imane El-Meouche, Ariane Amoura, Erick Denamur, Léo Hardy, Julia Bos, Tara Brosschot, Molly A Ingersoll, Eric Bacqué and 2 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manon LangInstitut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, 75015 Paris, France.ORCID 0000-0001-7843-4747
Stéphane RenardEvotec ID (Lyon) SAS, 69000 Lyon, France.ORCID 0000-0002-1374-4960
Imane El-MeoucheUniversité Paris Cité, INSERM UMR 1137 IAME, F-75018 Paris, France.
Ariane AmouraUniversité Paris Cité, INSERM UMR 1137 IAME, F-75018 Paris, France.
Erick DenamurUniversité Paris Cité, INSERM UMR 1137 IAME, F-75018 Paris, France.ORCID 0000-0002-7860-1717
Léo HardyInstitut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, 75015 Paris, France.ORCID 0009-0006-7852-4367
Julia BosInstitut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, 75015 Paris, France.ORCID 0000-0002-4947-4675
Tara BrosschotMucosal Inflammation and Immunity Team, Université Paris Cité, CNRS, Inserm, Institut Cochin, and Department of Immunology, Institut Pasteur, Paris, France.
Molly A IngersollMucosal Inflammation and Immunity Team, Université Paris Cité, CNRS, Inserm, Institut Cochin, and Department of Immunology, Institut Pasteur, Paris, France.ORCID 0000-0002-6388-7003
Eric BacquéEvotec ID (Lyon) SAS, 69000 Lyon, France.ORCID 0000-0002-9339-5050
Didier MazelInstitut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, 75015 Paris, France.ORCID 0000-0001-6482-6002
Zeynep BaharogluInstitut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, 75015 Paris, France.ORCID 0000-0003-3477-2685

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aminoglycosides (AGs) are broad-spectrum antibiotics effective against Gram-negative bacteria, with uptake dependent on membrane potential. However, the mechanisms of AG entry remain incompletely understood. Here, we identify a previously undescribed uptake pathway via carbohydrate transporters in

Indexed as

AminoglycosidesAnti-Bacterial AgentsMembrane Transport ProteinsUridineAnimalsBiological TransportDrug SynergismEscherichia coliHumansMiceMicrobial Sensitivity TestsUrinary Tract InfectionsAminoglycosidesAnti-Bacterial AgentsMembrane Transport ProteinsUridine

Identifiers

PMID40911672
PMCPMC12412646

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.