Evidence map›Paper›PMID 40911664›Full record

ArticleScience advances2025

Myo-inositol is a key regulator of avian metabolism: From mechanisms to seasonal behavior.

Adi Domer, Tyler R Misraje, Dianna Xing, B Gabriela Arango, Giovanna Selleghin-Veiga, Ammon Corl, Rauri C K Bowie, Jimmy A McGuire, Karen L Sweazea, José Pablo Vázquez-Medina and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Frontiers in physiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adi DomerDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-2289-4925
Tyler R MisrajeDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0009-0001-3951-0089
Dianna XingDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-4387-3613
B Gabriela ArangoDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-8942-9740
Giovanna Selleghin-VeigaDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-8332-4304
Ammon CorlDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-5156-4047
Rauri C K BowieDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-8328-6021
Jimmy A McGuireDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-9562-5585
Karen L SweazeaCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0000-0003-0345-4086
José Pablo Vázquez-MedinaDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-1014-5214
Robert DudleyDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-3707-5682

Funding

The Biology of Peroxiredoxin 6R35GM146951 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Jose P Vazquez Medina · 2022 to 2026
$2.1M
NIGMS NIH HHS R35 GM146951
6 · The paper itself

Abstract

Being naturally hyperglycemic and insulin insensitive, birds maintain plasma glucose levels twice as high as mammals of similar size. Recent evidence suggests that perturbation of myo-inositol (MI) plays a role in mammalian hyperglycemic regulation. Using an integrative approach, we identify a fundamental role of MI in avian metabolism. We show that MI transporters are highly conserved across birds and that dietary MI reduces fat accumulation in Anna's hummingbirds. MI consumption by hummingbirds varies with seasonal changes in body mass, consistent with a regulatory role. Furthermore, MI enhances fatty acid oxidation in avian cells, via effects on pyruvate-dehydrogenase complexes, indicating a role in mitochondrial fuel selection. Our findings underscore the importance of MI in avian metabolism, offering insights into their evolutionary adaptations in the context of insulin insensitivity.

Indexed as

BirdsInositolSeasonsAnimalsFatty AcidsMitochondriaOxidation-ReductionFatty AcidsInositol

Identifiers

PMID40911664
PMCPMC12412634

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.