Evidence map›Paper›PMID 40911601›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Ultracold cryogenic TEM with liquid helium and high stability.

Emily Rennich, Suk Hyun Sung, Nishkarsh Agarwal, Maya Gates, Robert Kerns, Robert Hovden, Ismail El Baggari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily Rennich *The Rowland Institute at Harvard, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-9147-4708
Suk Hyun Sung *The Rowland Institute at Harvard, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-7491-1988
Nishkarsh AgarwalDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109.
Maya GatesDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0009-0009-6281-3932
Robert KernsMichigan Center for Materials Characterization, University of Michigan, Ann Arbor, MI 48109.
Robert HovdenDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-3403-8803
Ismail El BaggariThe Rowland Institute at Harvard, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-6554-9289

Funding

US Department of Energy DE-SC0024147US National Science Foundation 2228909
6 · The paper itself

Abstract

Cryogenic transmission electron microscopy has revolutionized structural biology and materials science. To image below liquid nitrogen temperatures, various liquid helium stages have been constructed but have proven to be complex and unstable, making high-resolution imaging challenging. This problem is even more pronounced in side-entry specimen holders common on modern transmission electron microscopes. Here, we introduce an ultracold liquid helium transmission electron microscope side-entry specimen holder, featuring continuous cryogen flow and vibration decoupling. This instrument is compatible with modern aberration-corrected microscopes and achieves sub-25 K base temperature, [Formula: see text]2 mK thermal stability over many hours, and atomic resolution-setting the stage for a new era of cryogenic electron microscopy.

Indexed as

cryo-EMcryo-TEMelectron microscopyliquid helium

Identifiers

PMID40911601
PMCPMC12435197

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.