SynthesisImmunity, inflammation and disease2025
Assessing the Efficacy and Immunogenicity of Anticaries Vaccine-A Systematic Review and Meta-Analysis.
Synthesis in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing the Efficacy and Immunogenicity of Anticaries Vaccine-A Systematic Review and Meta-Analysis.Immunity, inflammation and disease · 2025Pooled it
- Recent Advances in Caries Prevention and Non-Invasive Management: From Ecological Modulation to Precision Interventions.Dentistry journal · 2026Review
- Mechanisms of caries induced by sugars: a narratives review from microbial metabolism to oral ecological imbalance and public health strategies for caries prevention.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivesThe current systematic review and meta-analysis aims to assess the safety and immunogenicity of the anticaries vaccines currently available. MATERIALS AND
methodsElectronic searches of PubMed, Scopus, Web of Science and Science Direct were performed. Studies assessing the safety and effectiveness of the anticaries vaccination, including the dose, plasmids, serum IgG and IgA levels after immunization, were included. Studies in which animals were used for anticaries vaccine were also included. Combining more than one trial was done to estimate the pooled intervention effect using the meta-analysis when studies examined the same intervention and outcomes with comparable methods in similar populations. The continuous data was pooled using the inverse variance method, and dichotomous data using the Mantel-Haenszel method.
resultsOut of 4701 records, only 17 publications met the eligibility criteria. Although all studies were assessed as having an overall low risk of bias, certain domains (D3, D5, and D7) exhibited a high risk across most studies. The pooled RR, derived using a random-effects model, was 0.53 (95% CI: 0.46-0.62), indicating a statistically significant 47% reduction in risk across studies.
conclusionsThere is excellent potential for dental caries vaccines to transform oral health in the future. Various vaccines, such as Killed Formalin-treated Donor strain 2 - recombinant Protein Antigen c and anti-CAT-SYIIgY antibodies, have demonstrated prophylactic effects against Streptococcus mutans colonization on teeth. These interventions exhibit a sustained reduction in S. mutans colonization, which may contribute to the prevention of dental caries. A vaccination of this kind would significantly lower tooth decay prevalence and the financial and health costs that go along with it.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.