Evidence map›Paper›PMID 40911404›Full record

ArticleThe Journal of physiology2025

Oxytocinergic signalling in the respiratory parafacial region increases the activity of chemosensitive neurons and respiratory output.

Emmanuel V Araujo, Phelipe E Silva, Luiz M Oliveira, Yingtang Shi, Ana C Takakura, Daniel K Mulkey, Thiago S Moreira

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emmanuel V AraujoDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, São Paulo, Brazil.
Phelipe E SilvaDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, São Paulo, Brazil.
Luiz M OliveiraCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-4071-4572
Yingtang ShiDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia, USA.
Ana C TakakuraDepartment of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0001-6273-0760
Daniel K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0002-7040-3927
Thiago S MoreiraDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0002-9789-8296

Funding

Glial chemosensitivity: pH sensing and interactions with neuronal chemoreceptorsR01HL104101 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, OLSEN, MICHELLE L · 2010 to 2024
$5.5M
Role of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1M
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 306580/2023-3Conselho Nacional de Desenvolvimento Científico e Tecnológicol 306418/2023-1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2020/08620-1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/05299-0Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/09377-6Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/09768-5Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2022/15609-0HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL104101HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL137094NHLBI NIH HHS R01 HL104101NHLBI NIH HHS R01 HL137094
6 · The paper itself

Abstract

The retrotrapezoid nucleus, located in the parafacial medullary region (RTN/pFRG), is crucial for respiratory activity and central chemoreception. Recent evidence suggests that neuromodulation, including peptidergic signalling, can influence the CO

Indexed as

Chemoreceptor CellsMedulla OblongataNeuronsOxytocinRespirationAnimalsMaleMiceMice, Inbred C57BLParaventricular Hypothalamic NucleusReceptors, OxytocinSignal TransductionOxytocinReceptors, Oxytocinbreathingcentral chemoreceptoroxytocinergic signallingRTN

Identifiers

PMID40911404
PMCPMC12487609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.