Evidence map›Paper›PMID 40911373›Full record

ArticleStatistics in medicine2025

Modeling Joint Health Effects of Environmental Exposure Mixtures With Bayesian Additive Regression Trees.

Jacob R Englert, Stefanie T Ebelt, Howard H Chang

Abstract read
In one paragraph

Article in Statistics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Multi-Tree Model for Precision Environmental Health with Longitudinally Assessed Mixture Exposure.Journal of the Royal Statistical Society. Series C, Applied statistics · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacob R EnglertDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-5416-3604
Stefanie T EbeltGangarosa Department of Environmental Health, Emory University, Atlanta, Georgia, USA.
Howard H ChangDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-6316-1640

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
Climate & Health Actionable Research and Translation CenterP20ES036110 · NIEHS · EMORY UNIVERSITY · PI CHANG, HOWARD H · 2023 to 2023
$3.9M
Extreme heat events and pregnancy duration: a national studyR01ES028346 · NIEHS · EMORY UNIVERSITY · PI CHANG, HOWARD H, DARROW, LYNDSEY · 2018 to 2024
$2.7M
New Statistical Methods for Estimating Health Effects of Environmental ExposuresR01ES037289 · NIEHS · EMORY UNIVERSITY · PI Howard H Chang · 2025 to 2026
$1.1M
NIEHS NIH HHS P20 ES036110NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES028346NIEHS NIH HHS R01 ES037289NIH HHS P20ES036110NIH HHS P30ES019776NIH HHS R01ES028346
6 · The paper itself

Abstract

Studying the association between mixtures of environmental exposures and health outcomes can be challenging due to issues such as correlation among the exposures and non-linearities or interactions in the exposure-response function. For this reason, one common strategy is to fit flexible nonparametric models to capture the true exposure-response surface. However, once such a model is fit, further decisions are required when it comes to summarizing the marginal and joint effects of the mixture on the outcome. In this work, we describe the use of soft Bayesian additive regression trees (BART) to estimate the exposure-risk surface describing the effect of mixtures of chemical air pollutants and temperature on asthma-related emergency department (ED) visits during the warm season in Atlanta, Georgia, from 2011 to 2018. BART is chosen for its ability to handle large datasets and for its flexibility to be incorporated as a single component of a larger model. We then summarize the results using a strategy known as accumulated local effects to extract meaningful insights into the mixture effects on asthma-related morbidity. Notably, we observe negative associations between

Indexed as

Environmental ExposureModels, StatisticalAir PollutantsAsthmaBayes TheoremEmergency Service, HospitalGeorgiaHumansOzoneRegression AnalysisSeasonsTemperatureAir PollutantsOzoneaccumulated local effectsair pollutionasthmaBayesian additive regression treesenvironmental mixtures

Identifiers

PMID40911373
PMCPMC12489876

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.