Evidence map›Paper›PMID 40911287›Full record

ArticleThe British journal of radiology2026

Prospective comparison of ultra-high-resolution photon-counting detector CT coronary angiography versus conventional CT.

Cynthia H McCollough, Aeden K Davis, Nikkole M Weber, Holly J Kasten, Elnata F Melka, Kishore Rajendran, Rickey E Carter, Shuai Leng

Abstract readComparative Study
In one paragraph

Article in The British journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cynthia H McColloughDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.ORCID 0000-0002-5346-332X
Aeden K DavisDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.
Nikkole M WeberDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.
Holly J KastenDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.
Elnata F MelkaDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.
Kishore RajendranDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.ORCID 0000-0002-8314-3642
Rickey E CarterDepartment of Health Science Research, Mayo Clinic, Jacksonville, FL 32224, United States.
Shuai LengDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.ORCID 0000-0002-6453-9481

Funding

Comprehensive characterization of coronary atherosclerotic disease using photon-counting-detector dual-source CT and its impact on patient managementR01EB028590 · NIBIB · MAYO CLINIC ROCHESTER · PI LENG, SHUAI, MCCOLLOUGH, CYNTHIA H · 2020 to 2023
$2.6M
NIBIB NIH HHS R01 EB028590NIH HHS R01 EB028590Siemens Healthcare
6 · The paper itself

Abstract

objectivesDetermine differences in quantitative stenosis severity measurements for ultra-high-resolution (UHR) photon-counting detector (PCD) coronary CT angiography (cCTA) relative to energy-integrating detector (EID) cCTA in a large patient cohort.

methodsAdult participants seen between November 2022 and March 2023 underwent a clinical dual-source EID-CT cCTA and a research dual-source PCD-CT cCTA on the same day. Percent diameter stenosis (PDS) was measured, and stenosis severity was assigned based on the PDS of the most severe lesion per patient to determine a coronary artery disease reporting and data system (CAD-RADS) score. Agreement between EID-CT and PCD-CT for PDS and CAD-RADS was determined.

resultsA total of 112 participants were enrolled, yielding 82 subjects with at least 1 stenosis at PCD-CT (mean age, 68.0 ± 10.8 years; 69.5% [57/82] males). A total of 177 paired stenoses were quantified. The percent decrease in mean PDS from PCD-CT (24.3%) to EID-CT (29.4%) was 17.3% (median difference in PDS: -5.0%, 95% CI: -5.7% to -4.0%). The assigned CAD-RADS score changed in 31/82 subjects. In 11/31 subjects, the most severe stenosis was missed at EID-CT due to partial volume averaging of a small calcification, yet PCD clearly identified stenosis at those locations. In 20/31 subjects, the CAD-RADS score decreased at PCD-CT due to the decreased calcium blooming resulting from the improved spatial resolution.

conclusionsUHR PCD cCTA decreases quantitative measures of stenosis severity when a stenosis is identified at EID, leading to decreases in CAD-RADS assignments. ADVANCES IN KNOWLEDGE: With its improved spatial resolution, PCD-CT identifies stenoses missed on EID-CT.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary StenosisAgedFemaleHumansMaleMiddle AgedPhotonsProspective StudiesSeverity of Illness IndexCAD-RADScoronary CT angiographyenergy-integrating-detector CTpercent diameter stenosisphoton-counting-detector CT

Identifiers

PMID40911287
PMCPMC12443222

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.