ArticleInternational ophthalmology2025
Corneal transplantation wound dehiscence after penetrating keratoplasty and deep anterior lamellar keratoplasty.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study clinical characteristics and outcomes of penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) wound dehiscence.
methodsThis retrospective case series assessed PK and DALK recipients with wound dehiscence at a single institution. We evaluated relationships between dehiscence etiologies, transplant indications, ocular/systemic comorbidities, keratoplasty type, and adverse post-dehiscence outcomes, especially graft failure and visual loss.
resultsWound dehiscence occurred in 97/1019 eyes (90/863 PK [10.4%] vs 7/156 DALK [4.5%]; p = 0.002). Median time to dehiscence was 6.6 months (range = 1 day-39.2 years). Primary causes included trauma (44.1%) and ulceration (36.1%). Leading surgical indications associated with dehiscence were microbial keratitis and corneal ectasia. Ocular surface disease, viral keratitis, glaucoma, diabetes, and smoking history were more prevalent in PK eyes. Graft failure post-dehiscence was more frequent after PK than DALK (61% vs 0%; p = 0.002) and more rapid with herpetic keratitis history (Log-Rank p = 0.02). Microbial keratitis-associated dehiscence was the strongest predictor of graft failure (odds ratio = 3.9, 95% CI 1.2-12.9). All 20 enucleations occurred in the PK group. Pre-dehiscence, PK eyes had worse habitually corrected visual acuity (HCVA; p = 0.008). Post-dehiscence, more PK eyes lost ≥ 2 Snellen lines (53.7% vs 14.3%; p = 0.058) and HCVA was worse than 20/200 (55.6% vs 0%; p = 0.005).
conclusionWound dehiscence is a serious keratoplasty complication that may be associated with graft failure and vision loss, especially after PK. Careful selection of transplantation techniques and application of therapeutic strategies tailored for the specific surgical indication and associated comorbidities should be used to mitigate the clinical course.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.