Evidence map›Paper›PMID 40911167›Full record

ArticleInfection2025

A fatal pediatric case of meningitis and streptococcal toxic shock syndrome caused by emm12 Streptococcus pyogenes strain in Jiangsu, China, 2024.

Lili Huang, Zhenhua Liu, Zhenjiang Bai, Mi Zhou, Panpan Lv, Yue Jiang, Mingliang Chen

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lili Huang *Laboratory Department, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhenhua Liu *Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
Zhenjiang BaiIntensive Care Unit, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Mi ZhouDepartment of Pharmacy, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Panpan LvDepartment of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
Yue JiangResearch and Translational Laboratory of Acute Injury and Secondary Infection, Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
Mingliang ChenDepartment of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China. cmlbright@126.com.

Funding

National Natural Science Foundation of China 82272381
6 · The paper itself

Abstract

A 23-month-old boy was admitted to our hospital with onset of fever and paroxysmal cough but progressed to death on Day 9. Streptococcus pyogenes was positive in cerebrospinal fluid and blood by next-generation sequencing, and was cultured from sputum. The isolate was resistant to erythromycin, clindamycin, and tetracycline. By genomic analysis, the isolate was identified to be emm12 of global Clade II and harbor mobile genetic elements of ICE-emm12 and ΦHKU.vir, carrying resistance genes ermB and tetM. We report a fatal case of meningitis case complicated with streptococcal toxic shock syndrome caused by emm12 S. pyogenes in China, which is rare in this country.

Indexed as

Meningitis, BacterialShock, SepticStreptococcal InfectionsStreptococcus pyogenesAnti-Bacterial AgentsChinaFatal OutcomeHumansInfantMaleMicrobial Sensitivity TestsAnti-Bacterial Agentsemm12FatalGenomic analysisStreptococcal toxic shock syndrome (STSS)Streptococcus pyogenes

Identifiers

PMID40911167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.