Evidence map›Paper›PMID 40911156›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Impact of In vitro Gastrointestinal Digestion on the Chemical Composition and Prebiotic Potential of Coffee Silverskin.

Marlene Machado, Iva Fernandes, Ana Fernandes, Liliana Espírito Santo, Cláudia Passos, Aroa Santamarina, Alejandra Cardelle-Cobas, Manuel A Coimbra, Maria B P P Oliveira, Helena Ferreira and 1 more

Abstract read
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marlene MachadoREQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. mcmachado@ff.up.pt.ORCID http://orcid.org/0000-0002-4104-4435
Iva FernandesDepartment of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007, Porto, Portugal.
Ana FernandesREQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences,, University of Porto, Rua do Campo Alegre, 1021-1055, 4169-007, Porto, Portugal.
Liliana Espírito SantoREQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Cláudia PassosREQUIMTE/LAQV, Department of Chemistry, Campus Universitário de Santiago, University of Aveiro, 3810-193, Aveiro, Portugal.
Aroa SantamarinaLaboratory - Food Hygiene, Inspection and Control, Department of Analytical Chemistry, Nutrition and Bromatology, University of Santiago de Compostela, 27002, Lugo, Spain.
Alejandra Cardelle-CobasLaboratory - Food Hygiene, Inspection and Control, Department of Analytical Chemistry, Nutrition and Bromatology, University of Santiago de Compostela, 27002, Lugo, Spain.
Manuel A CoimbraREQUIMTE/LAQV, Department of Chemistry, Campus Universitário de Santiago, University of Aveiro, 3810-193, Aveiro, Portugal.
Maria B P P OliveiraREQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Helena Ferreirai4HB, UCIBIO - Research Unit on Applied Molecular Biosciences, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. hferr@ff.up.pt.ORCID http://orcid.org/0000-0001-8465-6346
Rita C AlvesREQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. rcalves@ff.up.pt.ORCID http://orcid.org/0000-0002-5053-513X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing interest in prebiotic ingredients has led to the valorization of agri-food by-products, such as coffee silverskin, known for its richness in dietary fiber and health-promoting compounds. This study evaluated the impact of in vitro simulation of gastrointestinal digestion on the chemical composition (carbohydrates, caffeine, and chlorogenic acids) and prebiotic potential (probiotic growth, organic acid production, pH, and antioxidant activity) of milled coffee silverskin. The results show stability of polysaccharides during digestion, while caffeine and 5-caffeoylquinic acid were partially released into the bioaccessible fraction. The incubation of digested sample (DS) and the control (CS) with Lacticaseibacillus paracasei subsp. paracasei and Lactiplantibacillus plantarum subsp. plantarum resulted in probiotic growth, an increase in acetic acid production, and pH decrease. Following incubation, the cell-free supernatants of the DS and CS exhibited greater antioxidant activity compared to the negative control, glucose, and fructooligosaccharides. This study shows the functional potential of the whole silverskin due to its prebiotic and antioxidant properties.

Indexed as

CoffeaCoffeeDigestionGastrointestinal TractPrebioticsAntioxidantsCaffeineChlorogenic AcidDietary FiberHumansHydrogen-Ion ConcentrationLacticaseibacillus paracaseiOligosaccharidesPolysaccharidesProbioticsQuinic AcidAntioxidantsCaffeinecaffeoylquinic acidChlorogenic AcidCoffeeDietary FiberfructooligosaccharideOligosaccharidesPolysaccharidesPrebioticsQuinic AcidAntioxidant activityCoffee by-productOrganic acidsProbiotic

Identifiers

PMID40911156
PMCPMC12413342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.