Evidence map›Paper›PMID 40911124›Full record

ArticleMaternal and child health journal2025

Effects of Liver Enzyme Levels During Pregnancy on Birth Weight.

Qingxiu Li, Mian Pan, Jiayi Chen, Huimin Shi, Qian Zhang, Wenjuan Liu, Haiyan Gao, Wei Li, Zhengqin Wu, Bin Sun and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qingxiu Li *Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350004, China.
Mian Pan *Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, China.
Jiayi ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350004, China.
Huimin ShiDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350004, China.
Qian ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350004, China.
Wenjuan LiuFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, China.
Haiyan GaoFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, China.
Wei LiFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, China.
Zhengqin WuFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, China.
Bin SunFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, China.
Yibing ZhuFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, China. zybfmc@163.com.
Haibo LiDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350004, China. haiboli89@163.com.ORCID http://orcid.org/0000-0002-6512-3912

Funding

the Key Project on Science and Technology Program of Fujian Health Commission 2021ZD01002the National Natural Science Foundation of China (Youth Program) 82304156
6 · The paper itself

Abstract

objectivesTo investigate the association between maternal liver enzyme concentrations during pregnancy and the risk of abnormal birth weight.

methodsThis is a prospective birth cohort study querying the pregnant women from Fujian Maternal and Child Health Hospital, affiliated with Fujian Medical University, China. Liver enzyme levels, including gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were measured in the first and third trimesters, and changes in liver enzyme levels were calculated based on these measurements. The outcomes were birth weight, small for gestational age (SGA), large for gestational age (LGA), low birth weight (LBW), and macrosomia.

resultsThe study analyzed 19,003 singleton pregnancies with live births. The mean age of the pregnant individuals was 30.3 ± 3.9 years, 18,594 patients (97.8%) were Han. GGT in the first trimester is positively correlated with the risks of macrosomia and LBW, mediated through gestational diabetes mellitus (GDM) and gestational age at birth, respectively. Nonlinear regression models suggested that there was a linear relationship of liver enzyme levels during pregnancy with LBW and SGA (P for non-linear > 0.05). According to regression analysis, changes in liver enzyme levels during pregnancy were negatively correlated with birth weight, LGA, and macrosomia, and positively correlated with the risk of SGA. Similar results were found for liver enzymes in late pregnancy.

conclusionsThe concentration and even the changes of liver enzymes during pregnancy may influence the fetus's birth weight to different degrees. Thereby, monitoring liver enzyme levels during pregnancy could help prevent abnormal fetal development.

Indexed as

Birth WeightLiverAdultAlanine TransaminaseAspartate AminotransferasesChinaDiabetes, GestationalFemaleFetal Macrosomiagamma-GlutamyltransferaseGestational AgeHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgePregnancyAlanine TransaminaseAspartate Aminotransferasesgamma-GlutamyltransferaseLarge for gestational ageLiver enzymesLow birth weightMacrosomiaSmall for gestational age

Identifiers

PMID40911124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.