Evidence map›Paper›PMID 40911085›Full record

ArticleMarine biotechnology (New York, N.Y.)2025

Transcriptome Reveals Molecular Characteristics and Immune Response in Triploid Cyprinid Fish Infected with a Novel Pathogenic Aeromonas sp. AS1-4.

Qin-Yang He, Jie Peng, Ruo-Xing Yu, Ting Luo, Yao-Hui Li, Zi-Rou Zhong, Zi-Le Qin, Fei Wang, Jian Li, Sheng-Wei Luo

Abstract read
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In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qin-Yang HeEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Jie PengEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Ruo-Xing YuEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Ting LuoEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Yao-Hui LiEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Zi-Rou ZhongEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Zi-Le QinEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Fei WangEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Jian LiEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China.
Sheng-Wei LuoEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, 410081, People's Republic of China. swluo@hunnu.edu.cn.

Funding

National Key Research and Development Program of China, China 2023YFD2401601Project Foundation of Changsha Science and Technology Bureau, China kq2502141
6 · The paper itself

Abstract

Triploid cyprinid fish (TCF, 3N = 150) is a novel hybrid fish showing great disease resistance during aquaculture processes. However, the majority of Aeromonas strains act as opportunistic pathogens that can cause a variety of diseases and pose a notable health risk. In this investigation, a novel Aeromonas sp. AS1-4 was retrieved from the spleen (SPL) of moribund cyprinid fish. Whole genome sequencing (WGS) was employed to characterize its virulence features and signal regulation. Thereafter, TCFs were infected with strain AS1-4 for pathological analysis. Strain AS1-4 challenge could cause abnormal glycogen deposition in the liver (LIV) of TCFs, accompanied by significant alteration of physiological response. Furthermore, expression patterns of pivotal immune-related genes were markedly elevated in TCFs post-infection. Transcriptomic analysis revealed that strain AS1-4 infection may exert a profound impact on insulin signaling pathway and steroid biosynthesis. These results may contribute to the comprehension of molecular characteristics in fish infected with Aeromonas sp. AS1-4.

Indexed as

AeromonasCyprinidaeFish DiseasesGram-Negative Bacterial InfectionsTranscriptomeAnimalsLiverSpleenTriploidyVirulenceWhole Genome SequencingAeromonas strainGene expressionHybrid fishTranscriptome

Identifiers

PMID40911085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.