SynthesisDevelopmental medicine and child neurology2025
Active upper-limb therapies for hand function, individual goal achievement, and self-care in children with cerebral palsy: A network meta-analysis.
Synthesis in Developmental medicine and child neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Active upper-limb therapies for hand function, individual goal achievement, and self-care in children with cerebral palsy: A network meta-analysis.Developmental medicine and child neurology · 2025Pooled it
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Authors and funding
8 authors.
Funding
Abstract
aimTo compare active upper-limb therapies for children with cerebral palsy using a network meta-analysis.
methodFor this systematic review, five electronic databases were searched up to 2nd September 2024. Outcomes pertaining to improved hand use (Assisting Hand Assessment, AHA), goal attainment (Canadian Occupational Performance Measure, COPM), and self-care were analysed with therapies classified into 15 discrete categories.
resultsQuantitative analysis of 48 randomized controlled trials (n = 1629) was performed. Compared with control, treatment effect on hand function (AHA mean difference, standard error) was greater for bimanual therapy (BiM: 4.6, 1.0), modified constraint-induced movement therapy (mCIMT; 4.0, 1.0), goal-directed therapy (GDT; 3.8, 1.6), action observation (4.9, 1.1), and mCIMT + intensive (7.4, 2.5). For COPM performance, treatment effect was greater for cognitive orientation to occupational performance (CO-OP; 5.9, 1.4), BiM (3.3, 0.4), mCIMT (2.5, 0.5), GDT (2.3, 0.7), mirror therapy (2.6, 1.2), and mCIMT + GDT (4.2, 1.1). For self-care, treatment effect (standardized mean difference, standard error) was greater for BiM (0.39, 0.10), mCIMT (0.37, 0.08), and mCIMT + GDT (0.43, 0.32).
interpretationBiM and mCIMT were confirmed as effective interventions for hand function, self-care, and individual goal achievement. Mirror therapy, CO-OP, and four different combination approaches feature single studies, small sample sizes, and high risk of bias, requiring further clinical trials to confirm efficacy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.