Evidence map›Paper›PMID 40910882›Full record

ArticleRadiology. Imaging cancer2025

Using Machine Learning to Predict Advanced-Stage Progression of Intermediate-Stage Hepatocellular Carcinoma after Transarterial Chemoembolization.

Ran Wei, Zelong Liu, Lingjie Ju, Mengxuan Zuo, Wang Yao, Wang Li, Yan Fu, Wendao Liu, Chengzhi Li, Peihong Wu and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Radiology. Imaging cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Ran Wei *Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID 0009-0008-4619-0192
Zelong Liu *Department of Radiation Oncology, Cancer Center, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road, Guangzhou, China 510080.ORCID 0000-0001-6643-7772
Lingjie JuDepartment of Sonography, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0009-0007-7295-868X
Mengxuan ZuoDepartment of Minimal Invasive Intervention, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.ORCID 0000-0003-3589-7316
Wang YaoDepartment of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0003-1776-3031
Wang LiDepartment of Minimal Invasive Intervention, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.ORCID 0000-0002-4293-8182
Yan FuDepartment of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wendao LiuDepartment of Interventional Therapy, Guangdong Provincial Hospital of Chinese Medicine and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
Chengzhi LiDepartment of Interventional Radiology and Vascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Peihong WuDepartment of Minimal Invasive Intervention, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.ORCID 0000-0001-8008-1872
Jianjun HanInterventional Radiology Department, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Yaojun ZhangDepartment of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Jianfei TuDepartment of Radiology, Affiliated Lishui Hospital of Zhejiang University, Lishui, China.
Junhong RenDepartment of Sonography, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Chao An *Department of Minimal Invasive Intervention, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.ORCID 0000-0002-1096-4183
Zhenwei Peng *Department of Radiation Oncology, Cancer Center, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road, Guangzhou, China 510080.ORCID 0000-0002-0617-3805

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To develop and test a machine learning (ML)-based model that integrates preoperative variables for prediction of advanced-stage progression (ASP) after transarterial chemoembolization (TACE). Materials and Methods This multicenter retrospective study (ResearchRegistry.com identifier no. researchregistry9425) included patients with intermediate-stage hepatocellular carcinoma (HCC) who underwent TACE at seven hospitals from June 2008 to December 2022. Thirty-four preoperative clinical and CT imaging variables were input into six ML-based models for prediction of ASP, and model performances were compared. Furthermore, the best-performing ML model was compared with the major staging systems, and its utility in performing post-TACE therapies was assessed. The performances of the models were compared by using area under the receiver operating characteristic curve (AUC) with DeLong test. Kaplan-Meier survival curves were compared using the log-rank test. Results A total of 2333 eligible patients (mean age, 54 years ± 12 [SD]; 2051 male patients) were categorized into the training set (

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsMachine LearningAdultAgedDisease ProgressionFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesTomography, X-Ray ComputedAdvanced-stage ProgressionHepatocellular CarcinomaLiverMachine LearningOncologyRisk DifferentiationTransarterial Chemoembolization

Identifiers

PMID40910882
PMCPMC12492425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.