Evidence map›Paper›PMID 40910871›Full record

ArticleBiochemistry2025

Structural Elements of Dwarf Open Reading Frame Required for Activation of the Sarco-Endoplasmic Reticulum Calcium Pump.

M'Lynn E Fisher, Justin R Gregory, Stan T J Aanhane, M Joanne Lemieux, Howard S Young

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M'Lynn E FisherDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Justin R GregoryDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Stan T J AanhaneDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0009-0006-2175-7012
M Joanne LemieuxDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0000-0003-4745-9153
Howard S YoungDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0000-0002-5990-8422

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sarco-endoplasmic reticulum calcium pump (SERCA) is a P-type ATPase that plays a critical role in intracellular calcium signaling. SERCA maintains the calcium gradient between the cytosol and the sarco-endoplasmic reticulum, which is essential for a variety of physiological events including the muscle contraction-relaxation cycle. In cardiac muscle, SERCA is regulated by transmembrane peptides phospholamban (PLN) and dwarf open reading frame (DWORF). These peptides encode the opposing functions of SERCA inhibition by PLN and SERCA activation by DWORF, though the underlying mechanisms remain unclear. Herein, we investigated structural elements of DWORF expected to play a role in SERCA activation. We first measured SERCA activity in the absence and presence of DWORF variants targeting Leu

Indexed as

Calcium-Binding ProteinsSarcoplasmic Reticulum Calcium-Transporting ATPasesAmino Acid SequenceAnimalsEnzyme ActivationHumansPhospholambanCalcium-Binding ProteinsPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID40910871
PMCPMC12445340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.