Evidence map›Paper›PMID 40910779›Full record

ArticleMicrobiology spectrum2025

Identification of beneficial symbiont candidates in commensalism as potential oral gatekeepers.

Soutaro Hanawa, Aoi Son, Tamotsu Kato, Yoshiyuki Matsuo, Takayuki Omae, Yuji Omori, Kyohei Yoshikawa, Koji Yamanegi, Kiichi Hirota, Hiroshi Ohno and 4 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Soutaro HanawaDepartment of Oral & Maxillofacial Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Aoi SonDepartment of Microbiology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Tamotsu KatoLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Yoshiyuki MatsuoDepartment of Human Stress Response Science, Institute of Biomedical Scienc, Kansai Medical University, Hirakata, Osaka, Japan.
Takayuki OmaeDepartment of Oral & Maxillofacial Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Yuji OmoriDepartment of Oral & Maxillofacial Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Kyohei YoshikawaDepartment of Oral & Maxillofacial Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Koji YamanegiDepartment of Pathology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Kiichi HirotaDepartment of Human Stress Response Science, Institute of Biomedical Scienc, Kansai Medical University, Hirakata, Osaka, Japan.
Hiroshi OhnoLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Hideki OguraDepartment of Microbiology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Satoshi IshidoDepartment of Microbiology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.ORCID 0000-0001-5893-3354
Kazuma NoguchiDepartment of Oral & Maxillofacial Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.ORCID 0009-0007-5082-2327
Hiromitsu KishimotoDepartment of Oral & Maxillofacial Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.ORCID 0009-0009-9326-346X

Funding

Hyogo College of MedicineJapan Society for the Promotion of Science JP22K09106Japan Society for the Promotion of Science JP23H05357
6 · The paper itself

Abstract

The basis of the development of oral cancer has been reported to be inflammation (e.g., periodontitis) caused by dysbiosis of the oral microbiota (i.e., a decrease in beneficial oral symbionts). Since a decrease in beneficial symbionts is connected to oral cancer, restoring these bacteria may help prevent it. Based on this, oral probiotics using beneficial oral symbionts are under development. Therefore, it is necessary to understand how beneficial oral symbionts are maintained in a healthy oral cavity. We evaluated a cohort consisting of 42 healthy volunteers and 39 oral cancer patients via 16S metagenomic analysis. Beneficial symbiont candidates were mined by comparing the oral microbiota of healthy volunteers with that of oral cancer patients, and the interaction mode among the beneficial symbiont candidates was further examined. Cancer patients exhibited decreased relative abundance of the genera

Indexed as

BacteriaMouthMouth NeoplasmsSymbiosisAdultAgedDysbiosisFemaleHealthy VolunteersHumansMaleMicrobiotaMiddle AgedProbioticsRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbeneficial symbiontgenus Rothiagenus Streptococcusoral microbiotaprobioticssyntrophic interaction

Identifiers

PMID40910779
PMCPMC12502559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.